Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091298650> ?p ?o ?g. }
- W2091298650 endingPage "403" @default.
- W2091298650 startingPage "393" @default.
- W2091298650 abstract "The analysis of the molecular mechanisms involved in the initial interaction between neurons and Schwann cells is a key issue in understanding the myelination process. We recently identified Cthrc1 (Collagen triple helix repeat containing 1) as a gene upregulated in Schwann cells upon interaction with the axon. Cthrc1 encodes a secreted protein previously shown to be involved in migration and proliferation in different cell types. We performed a functional analysis of Cthrc1 in Schwann cells by loss-of- and gain-of-function approaches using RNA interference knockdown in cell culture and a transgenic mouse line that overexpresses the gene. This work establishes that Cthrc1 enhances Schwann cell proliferation but prevents myelination. In particular, time-course analysis of myelin formation intransgenic animals reveals that overexpression of Cthrc1 in Schwann cells leads to a delay in myelin formation with cells maintaining a proliferative state. Our data, therefore, demonstrate that Cthrc1 plays a negative regulatory role, fine-tuning the onset of peripheral myelination." @default.
- W2091298650 created "2016-06-24" @default.
- W2091298650 creator A5004177638 @default.
- W2091298650 creator A5020075483 @default.
- W2091298650 creator A5034177785 @default.
- W2091298650 creator A5036660299 @default.
- W2091298650 creator A5037174564 @default.
- W2091298650 creator A5048570321 @default.
- W2091298650 creator A5061430292 @default.
- W2091298650 creator A5068808545 @default.
- W2091298650 creator A5069225949 @default.
- W2091298650 date "2011-12-22" @default.
- W2091298650 modified "2023-10-14" @default.
- W2091298650 title "Cthrc1 is a negative regulator of myelination in schwann cells" @default.
- W2091298650 cites W1503103177 @default.
- W2091298650 cites W1964742026 @default.
- W2091298650 cites W1965714383 @default.
- W2091298650 cites W1967364883 @default.
- W2091298650 cites W1972370965 @default.
- W2091298650 cites W1976731473 @default.
- W2091298650 cites W1986748157 @default.
- W2091298650 cites W1999944134 @default.
- W2091298650 cites W2000129128 @default.
- W2091298650 cites W2028818779 @default.
- W2091298650 cites W2028934778 @default.
- W2091298650 cites W2038502326 @default.
- W2091298650 cites W2044837704 @default.
- W2091298650 cites W2054976402 @default.
- W2091298650 cites W2059476607 @default.
- W2091298650 cites W2064588350 @default.
- W2091298650 cites W2068059177 @default.
- W2091298650 cites W2071515540 @default.
- W2091298650 cites W2071687921 @default.
- W2091298650 cites W2082176618 @default.
- W2091298650 cites W2085467313 @default.
- W2091298650 cites W2092322285 @default.
- W2091298650 cites W2092443716 @default.
- W2091298650 cites W2093986241 @default.
- W2091298650 cites W2094368236 @default.
- W2091298650 cites W2096027130 @default.
- W2091298650 cites W2099455244 @default.
- W2091298650 cites W2103179205 @default.
- W2091298650 cites W2113404473 @default.
- W2091298650 cites W2120442017 @default.
- W2091298650 cites W2143866689 @default.
- W2091298650 cites W2143908316 @default.
- W2091298650 cites W2148732408 @default.
- W2091298650 cites W2154862276 @default.
- W2091298650 cites W2155277867 @default.
- W2091298650 cites W2155460347 @default.
- W2091298650 cites W2159228290 @default.
- W2091298650 doi "https://doi.org/10.1002/glia.22273" @default.
- W2091298650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3505855" @default.
- W2091298650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22379615" @default.
- W2091298650 hasPublicationYear "2011" @default.
- W2091298650 type Work @default.
- W2091298650 sameAs 2091298650 @default.
- W2091298650 citedByCount "14" @default.
- W2091298650 countsByYear W20912986502014 @default.
- W2091298650 countsByYear W20912986502015 @default.
- W2091298650 countsByYear W20912986502016 @default.
- W2091298650 countsByYear W20912986502017 @default.
- W2091298650 countsByYear W20912986502018 @default.
- W2091298650 countsByYear W20912986502020 @default.
- W2091298650 countsByYear W20912986502022 @default.
- W2091298650 countsByYear W20912986502023 @default.
- W2091298650 crossrefType "journal-article" @default.
- W2091298650 hasAuthorship W2091298650A5004177638 @default.
- W2091298650 hasAuthorship W2091298650A5020075483 @default.
- W2091298650 hasAuthorship W2091298650A5034177785 @default.
- W2091298650 hasAuthorship W2091298650A5036660299 @default.
- W2091298650 hasAuthorship W2091298650A5037174564 @default.
- W2091298650 hasAuthorship W2091298650A5048570321 @default.
- W2091298650 hasAuthorship W2091298650A5061430292 @default.
- W2091298650 hasAuthorship W2091298650A5068808545 @default.
- W2091298650 hasAuthorship W2091298650A5069225949 @default.
- W2091298650 hasBestOaLocation W20912986503 @default.
- W2091298650 hasConcept C104317684 @default.
- W2091298650 hasConcept C127561419 @default.
- W2091298650 hasConcept C166703698 @default.
- W2091298650 hasConcept C169760540 @default.
- W2091298650 hasConcept C173396325 @default.
- W2091298650 hasConcept C2777004073 @default.
- W2091298650 hasConcept C2778609137 @default.
- W2091298650 hasConcept C2779530196 @default.
- W2091298650 hasConcept C529278444 @default.
- W2091298650 hasConcept C54355233 @default.
- W2091298650 hasConcept C67705224 @default.
- W2091298650 hasConcept C6929976 @default.
- W2091298650 hasConcept C81885089 @default.
- W2091298650 hasConcept C86803240 @default.
- W2091298650 hasConcept C95444343 @default.
- W2091298650 hasConceptScore W2091298650C104317684 @default.
- W2091298650 hasConceptScore W2091298650C127561419 @default.
- W2091298650 hasConceptScore W2091298650C166703698 @default.
- W2091298650 hasConceptScore W2091298650C169760540 @default.
- W2091298650 hasConceptScore W2091298650C173396325 @default.
- W2091298650 hasConceptScore W2091298650C2777004073 @default.