Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091299472> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2091299472 endingPage "799" @default.
- W2091299472 startingPage "797" @default.
- W2091299472 abstract "Preneoplastic and neoplastic lesions induced by peroxisome proliferators in the livers of rats and mice do not express gamma-glutamyltranspeptidase (GGT). Previous studies have shown that the absence of GGT is not due to the toxic effect of peroxisome proliferators or due to the presence of inactive enzyme. The present experiment was designed to examine whether the GGT-negative property of these lesions is stable and irreversible or whether these lesions can be modulated to express GGT by 2-acetylaminofluorene (AAF). Hepatic lesions were induced in F-344 rats by feeding ciprofibrate (0.025%) in diet for 60 or 84 weeks. These rats were then administered AAF in diet (0.02%) for 5 weeks and the altered areas (AAs), neoplastic nodules (NNs) and hepatocellular carcinomas were analyzed for the expression of GGT. Ninety per cent of carcinomas, 90-100% of NNs and greater than 60% AAs were negative for GGT following AAF treatment. These results are very similar to the phenotypic features observed in the livers of rats treated with ciprofibrate alone. The results of this study suggest that the GGT-negative property of ciprofibrate-induced lesions is stable and not modulatable by AAF." @default.
- W2091299472 created "2016-06-24" @default.
- W2091299472 creator A5022894733 @default.
- W2091299472 creator A5034754078 @default.
- W2091299472 creator A5046172306 @default.
- W2091299472 creator A5056427517 @default.
- W2091299472 creator A5076453661 @default.
- W2091299472 date "1989-01-01" @default.
- W2091299472 modified "2023-10-16" @default.
- W2091299472 title "γ-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration" @default.
- W2091299472 doi "https://doi.org/10.1093/carcin/10.4.797" @default.
- W2091299472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2564815" @default.
- W2091299472 hasPublicationYear "1989" @default.
- W2091299472 type Work @default.
- W2091299472 sameAs 2091299472 @default.
- W2091299472 citedByCount "10" @default.
- W2091299472 crossrefType "journal-article" @default.
- W2091299472 hasAuthorship W2091299472A5022894733 @default.
- W2091299472 hasAuthorship W2091299472A5034754078 @default.
- W2091299472 hasAuthorship W2091299472A5046172306 @default.
- W2091299472 hasAuthorship W2091299472A5056427517 @default.
- W2091299472 hasAuthorship W2091299472A5076453661 @default.
- W2091299472 hasConcept C114246631 @default.
- W2091299472 hasConcept C126322002 @default.
- W2091299472 hasConcept C127078168 @default.
- W2091299472 hasConcept C134018914 @default.
- W2091299472 hasConcept C142724271 @default.
- W2091299472 hasConcept C170493617 @default.
- W2091299472 hasConcept C181199279 @default.
- W2091299472 hasConcept C2779838395 @default.
- W2091299472 hasConcept C2781278919 @default.
- W2091299472 hasConcept C2910266098 @default.
- W2091299472 hasConcept C55493867 @default.
- W2091299472 hasConcept C71924100 @default.
- W2091299472 hasConcept C86803240 @default.
- W2091299472 hasConcept C87644729 @default.
- W2091299472 hasConceptScore W2091299472C114246631 @default.
- W2091299472 hasConceptScore W2091299472C126322002 @default.
- W2091299472 hasConceptScore W2091299472C127078168 @default.
- W2091299472 hasConceptScore W2091299472C134018914 @default.
- W2091299472 hasConceptScore W2091299472C142724271 @default.
- W2091299472 hasConceptScore W2091299472C170493617 @default.
- W2091299472 hasConceptScore W2091299472C181199279 @default.
- W2091299472 hasConceptScore W2091299472C2779838395 @default.
- W2091299472 hasConceptScore W2091299472C2781278919 @default.
- W2091299472 hasConceptScore W2091299472C2910266098 @default.
- W2091299472 hasConceptScore W2091299472C55493867 @default.
- W2091299472 hasConceptScore W2091299472C71924100 @default.
- W2091299472 hasConceptScore W2091299472C86803240 @default.
- W2091299472 hasConceptScore W2091299472C87644729 @default.
- W2091299472 hasIssue "4" @default.
- W2091299472 hasLocation W20912994721 @default.
- W2091299472 hasLocation W20912994722 @default.
- W2091299472 hasOpenAccess W2091299472 @default.
- W2091299472 hasPrimaryLocation W20912994721 @default.
- W2091299472 hasRelatedWork W1966504330 @default.
- W2091299472 hasRelatedWork W1968562427 @default.
- W2091299472 hasRelatedWork W1979139803 @default.
- W2091299472 hasRelatedWork W2004337431 @default.
- W2091299472 hasRelatedWork W2037631372 @default.
- W2091299472 hasRelatedWork W2062510470 @default.
- W2091299472 hasRelatedWork W2091299472 @default.
- W2091299472 hasRelatedWork W2156651750 @default.
- W2091299472 hasRelatedWork W2176854638 @default.
- W2091299472 hasRelatedWork W2748952813 @default.
- W2091299472 hasVolume "10" @default.
- W2091299472 isParatext "false" @default.
- W2091299472 isRetracted "false" @default.
- W2091299472 magId "2091299472" @default.
- W2091299472 workType "article" @default.