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• W2091309985 startingPage "6050" @default.
• W2091309985 abstract "NRIF (neurotrophin receptor interacting factor) is a ubiquitously expressed zinc finger protein of the Krüppel family which interacts with the neurotrophin receptor p75(NTR). The interaction was first detected in yeast and then biochemically confirmed using recombinant GST-NRIF fusions and p75(NTR) expressed by eukaryotic cells. Transgenic mice carrying a deletion in the exon encoding the p75(NTR)-binding domain of NRIF display a phenotype which is strongly dependent upon genetic background. While at the F(2 )generation there is only limited (20%) embryonic lethality, in a congenic BL6 strain nrif(-/-) mice cannot survive beyond E12, but are viable and healthy to adulthood in the Sv129 background. The involvement of NRIF in p75(NTR)/NGF-mediated developmental cell death was examined in the mouse embryonic neural retina. Disruption of the nrif gene leads to a reduction in cell death which is quantitatively indistinguishable from that observed in p75(NTR)(-/-) and ngf(-/-) mice. These results indicate that NRIF is an intracellular p75(NTR)-binding protein transducing cell death signals during development." @default.
• W2091309985 created "2016-06-24" @default.
• W2091309985 creator A5042106814 @default.
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• W2091309985 creator A5078900856 @default.
• W2091309985 creator A5086563058 @default.
• W2091309985 date "1999-11-01" @default.
• W2091309985 modified "2023-10-18" @default.
• W2091309985 title "The zinc finger protein NRIF interacts with the neurotrophin receptor p75NTR and participates in programmed cell death" @default.
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• W2091309985 doi "https://doi.org/10.1093/emboj/18.21.6050" @default.
• W2091309985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1171670" @default.
• W2091309985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10545116" @default.
• W2091309985 hasPublicationYear "1999" @default.
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