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• W2091317246 abstract "We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells. Six cell lines derived from human pancreatic cancers were examined, and AsPC-1 and PANC-1 were noted to express AFP. Single cell culture assays and xenotransplantation revealed that the AFP-producing cells had the capacity for self-renewal and differentiation, and that these cells were tumorigenic. Furthermore, they were resistant to anti-cancer agents. The ABCA12 transporter was expressed in the AFP-producing cells at a level more than twice as high as that in the non-AFP-producing cells. The AFP-producing cells were shown to be putative pancreatic cancer stem cells. Furthermore, the expression of ABCA12 appears to be associated with drug resistance." @default.
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• W2091317246 date "2011-09-01" @default.
• W2091317246 modified "2023-10-14" @default.
• W2091317246 title "Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics" @default.
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• W2091317246 doi "https://doi.org/10.1016/j.canlet.2011.04.023" @default.
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