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- W2091320610 abstract "Experimental evidence exists to suggest that zinc can have positive and negative effects on the physiology of cells depending on the local concentration, localisation (extracellular vs. intracellular) and/or state (bound vs. free). The retina contains particularly high amounts of zinc suggesting a pivotal role in the tissue. There is also suggestive evidence that zinc deficiency in humans may result in abnormal dark adaptation and/or age-related macular degeneration. The purpose of this article is to provide an overview of various proposed functions for zinc, particularly in the retina. Endogenous chelatable zinc in the retina is localised mainly to the photoreceptors and retinal pigment epithelial cells. Moreover, the zinc localisation in the photoreceptors varies in dark and light, suggesting a role for zinc in a light-regulated process. Some zinc is also located to other areas of the retina but clearly defined zinc-enriched neurones could not be identified as has been shown to occur in certain areas of the brain. Neurones post-synaptic to zinc-enriched neurones in the brain have been suggested to be particularly vulnerable in ischaemia. The role of zinc in retinal ischaemia has been investigated to determine how it is involved in the process. It would appear that when zinc is administered in low concentrations it generally has a positive effect on an insulted retina as in ischaemia. However, higher concentrations of zinc exacerbates the influence of the insult and also acts as a toxin. Use of zinc supplements in diet must, therefore, be taken with caution." @default.
- W2091320610 created "2016-06-24" @default.
- W2091320610 creator A5069352403 @default.
- W2091320610 creator A5073697420 @default.
- W2091320610 date "2001-06-01" @default.
- W2091320610 modified "2023-09-24" @default.
- W2091320610 title "Zinc in the retina" @default.
- W2091320610 cites W1491463220 @default.
- W2091320610 cites W1493393750 @default.
- W2091320610 cites W1497982073 @default.
- W2091320610 cites W1535873009 @default.
- W2091320610 cites W1545990390 @default.
- W2091320610 cites W157666778 @default.
- W2091320610 cites W1576798989 @default.
- W2091320610 cites W1612987016 @default.
- W2091320610 cites W1616090194 @default.
- W2091320610 cites W1649693286 @default.
- W2091320610 cites W1734082729 @default.
- W2091320610 cites W1772604871 @default.
- W2091320610 cites W1817392531 @default.
- W2091320610 cites W1849874806 @default.
- W2091320610 cites W1891136408 @default.
- W2091320610 cites W1963939517 @default.
- W2091320610 cites W1963947549 @default.
- W2091320610 cites W1964502095 @default.
- W2091320610 cites W1965261878 @default.
- W2091320610 cites W1966033732 @default.
- W2091320610 cites W1967989911 @default.
- W2091320610 cites W1968267810 @default.
- W2091320610 cites W1969236532 @default.
- W2091320610 cites W1971192189 @default.
- W2091320610 cites W1971575492 @default.
- W2091320610 cites W1972173896 @default.
- W2091320610 cites W1972614641 @default.
- W2091320610 cites W1977222846 @default.
- W2091320610 cites W1979406476 @default.
- W2091320610 cites W1979929247 @default.
- W2091320610 cites W1980173052 @default.
- W2091320610 cites W1982160831 @default.
- W2091320610 cites W1982569456 @default.
- W2091320610 cites W1983310681 @default.
- W2091320610 cites W1984745753 @default.
- W2091320610 cites W1985364907 @default.
- W2091320610 cites W1985967507 @default.
- W2091320610 cites W1989684741 @default.
- W2091320610 cites W1989965028 @default.
- W2091320610 cites W1990345603 @default.
- W2091320610 cites W1990465549 @default.
- W2091320610 cites W1990645765 @default.
- W2091320610 cites W1990697514 @default.
- W2091320610 cites W1991229325 @default.
- W2091320610 cites W1991647860 @default.
- W2091320610 cites W1993097538 @default.
- W2091320610 cites W1993470377 @default.
- W2091320610 cites W1993736839 @default.
- W2091320610 cites W1994000567 @default.
- W2091320610 cites W1995957068 @default.
- W2091320610 cites W1996481063 @default.
- W2091320610 cites W1997152666 @default.
- W2091320610 cites W1998013941 @default.
- W2091320610 cites W1998648184 @default.
- W2091320610 cites W2000297390 @default.
- W2091320610 cites W2000549923 @default.
- W2091320610 cites W2000587840 @default.
- W2091320610 cites W2002536790 @default.
- W2091320610 cites W2002945872 @default.
- W2091320610 cites W2004007082 @default.
- W2091320610 cites W2005161708 @default.
- W2091320610 cites W2007111898 @default.
- W2091320610 cites W2007147751 @default.
- W2091320610 cites W2008592285 @default.
- W2091320610 cites W2010674477 @default.
- W2091320610 cites W2012921140 @default.
- W2091320610 cites W2013547432 @default.
- W2091320610 cites W2013770493 @default.
- W2091320610 cites W2013798703 @default.
- W2091320610 cites W2013986174 @default.
- W2091320610 cites W2016532781 @default.
- W2091320610 cites W2016743484 @default.
- W2091320610 cites W2017393429 @default.
- W2091320610 cites W2017597839 @default.
- W2091320610 cites W2018566513 @default.
- W2091320610 cites W2018883950 @default.
- W2091320610 cites W2019869230 @default.
- W2091320610 cites W2020368543 @default.
- W2091320610 cites W2020709143 @default.
- W2091320610 cites W2020934096 @default.
- W2091320610 cites W2021478538 @default.
- W2091320610 cites W2021690131 @default.
- W2091320610 cites W2022164177 @default.
- W2091320610 cites W2022371229 @default.
- W2091320610 cites W2022382515 @default.
- W2091320610 cites W2022635808 @default.
- W2091320610 cites W2024105385 @default.
- W2091320610 cites W2024838009 @default.
- W2091320610 cites W2027642546 @default.
- W2091320610 cites W2031458931 @default.
- W2091320610 cites W2031702150 @default.