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• W2091323786 startingPage "261" @default.
• W2091323786 abstract "Ca2+ homeostasis controls a diversity of cellular processes including proliferation and apoptosis. A very important aspect of Ca2+ signaling is how different Ca2+ signals are translated into specific cell functions. In T cells, Ca2+ signals are induced following the recognition of antigen by the T cell receptor and depend mainly on Ca2+ influx through store-operated CRAC channels, which are mediated by ORAI proteins following their activation by STIM proteins. The complete absence of Ca2+ influx caused by mutations in Stim1 and Orai1 leads to severe immunodeficiency. Here we summarize how Ca2+ signals are tuned to regulate important T cell functions as proliferation, apoptosis and tolerance, the latter one being a special state of immune cells in which they can no longer respond properly to an otherwise activating stimulus. Perturbations of Ca2+ signaling may be linked to immune suppressive diseases and autoimmune diseases." @default.
• W2091323786 created "2016-06-24" @default.
• W2091323786 creator A5025836224 @default.
• W2091323786 creator A5042704555 @default.
• W2091323786 creator A5045126391 @default.
• W2091323786 creator A5063907700 @default.
• W2091323786 creator A5085704368 @default.
• W2091323786 date "2011-09-01" @default.
• W2091323786 modified "2023-10-06" @default.
• W2091323786 title "ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance" @default.
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• W2091323786 doi "https://doi.org/10.1016/j.ceca.2011.05.015" @default.

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