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• W2091330203 abstract "Summary Seventy F usarium isolates derived from human keratomycosis were identified based on partial sequences of the β‐tubulin ( β‐ TUB ) and translation elongation factor 1α ( EF ‐1α ) genes. Most of the isolates were confirmed as members of the F . solani species complex (75.71%), followed by the F . dimerum species complex (8.57%), the F . fujikuroi species complex (8.57%), the F . oxysporum species complex (4.29%) and the F . incarnatum‐equiseti species complex (2.86%). A combined phylogenetic tree was estimated including all the 70 isolates. Isolates belonging to different species complexes formed separate clades. In this study, we also report the first isolation of F . napiforme from human keratomycosis. A new method based on a specific Eco RI restriction site in the EF ‐1α gene was developed for the rapid identification of F . solani . In vitro antifungal susceptibilities of the isolates to seven antifungals were determined by broth microdilution method. Terbinafine, natamycin and amphotericin B proved to be the most effective drugs, followed by voriconazole. The minimal inhibitory concentrations of clotrimazole, econazole and itraconazole were generally high (≥64 μg ml −1 ). The interactions between the two most effective antifungals (natamycin and terbinafine) were determined by checkerboard microdilution method. Synergism (71.8%) or no interaction (28.2%) was revealed between the two compounds." @default.
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• W2091330203 date "2013-02-26" @default.
• W2091330203 modified "2023-10-04" @default.
• W2091330203 title "<i>Fusarium</i>keratitis in South India: causative agents, their antifungal susceptibilities and a rapid identification method for the<i>Fusarium solani</i>species complex" @default.
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• W2091330203 doi "https://doi.org/10.1111/myc.12062" @default.
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