Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091333504> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2091333504 endingPage "819" @default.
- W2091333504 startingPage "805" @default.
- W2091333504 abstract "Ofloxacin, its optical isomers levofloxacin (HR 355, DR-3355) and D-ofloxacm (DR-3354) and ciprofloxacin were administered orally to mice and rats which had systemic and localized infections. Both levofloxacin and ciprofloxacin were equally effective in treating systemic murine infections caused by staphylococci, Enterobacteriaceae or Pseudomonas aeruginosa with ED50S ranging from 0·18 to 15·8 mg/kg and 0·42 to 16·3 mg/kg respectively and both these agents were twice as effective as ofloxacin which had an ED50 0·41 to 39·7 mg/kg. In contrast, D-ofloxacin was either inactive or exhibited only modest chemotherapeutic activity against the staphylococci and the Gram-negative organisms tested. When given to mice to treat staphylococcal abscesses and lung infections due to Klebsiella pneumoniae DT-S levofloxacin was up to four times more effective and produced a more pronounced bactericidal effect against the pathogens in vivo than the reference compounds.Despite possessing a similar, if not lesser, in-vitro activity against the infecting pathogens, levofloxacin was more effective than ofloxacin and ciprofloxacin in rats with localized infections caused by Enterobacteriaceae and P. aeruginosa." @default.
- W2091333504 created "2016-06-24" @default.
- W2091333504 creator A5036268038 @default.
- W2091333504 creator A5036554952 @default.
- W2091333504 creator A5043458246 @default.
- W2091333504 creator A5057834813 @default.
- W2091333504 creator A5061686393 @default.
- W2091333504 creator A5066930310 @default.
- W2091333504 creator A5077654957 @default.
- W2091333504 creator A5078443958 @default.
- W2091333504 creator A5086366346 @default.
- W2091333504 date "1995-01-01" @default.
- W2091333504 modified "2023-10-16" @default.
- W2091333504 title "Chemotherapeutic activity of levofloxacin (HR 355, DR-3355) against systemic and localized infections in laboratory animals" @default.
- W2091333504 doi "https://doi.org/10.1093/jac/35.6.805" @default.
- W2091333504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7559192" @default.
- W2091333504 hasPublicationYear "1995" @default.
- W2091333504 type Work @default.
- W2091333504 sameAs 2091333504 @default.
- W2091333504 citedByCount "26" @default.
- W2091333504 countsByYear W20913335042012 @default.
- W2091333504 countsByYear W20913335042013 @default.
- W2091333504 countsByYear W20913335042017 @default.
- W2091333504 countsByYear W20913335042018 @default.
- W2091333504 countsByYear W20913335042020 @default.
- W2091333504 countsByYear W20913335042021 @default.
- W2091333504 crossrefType "journal-article" @default.
- W2091333504 hasAuthorship W2091333504A5036268038 @default.
- W2091333504 hasAuthorship W2091333504A5036554952 @default.
- W2091333504 hasAuthorship W2091333504A5043458246 @default.
- W2091333504 hasAuthorship W2091333504A5057834813 @default.
- W2091333504 hasAuthorship W2091333504A5061686393 @default.
- W2091333504 hasAuthorship W2091333504A5066930310 @default.
- W2091333504 hasAuthorship W2091333504A5077654957 @default.
- W2091333504 hasAuthorship W2091333504A5078443958 @default.
- W2091333504 hasAuthorship W2091333504A5086366346 @default.
- W2091333504 hasConcept C104317684 @default.
- W2091333504 hasConcept C150903083 @default.
- W2091333504 hasConcept C185592680 @default.
- W2091333504 hasConcept C207001950 @default.
- W2091333504 hasConcept C2777058267 @default.
- W2091333504 hasConcept C2777637488 @default.
- W2091333504 hasConcept C2778049240 @default.
- W2091333504 hasConcept C2778512257 @default.
- W2091333504 hasConcept C2778910516 @default.
- W2091333504 hasConcept C2781276175 @default.
- W2091333504 hasConcept C3019249092 @default.
- W2091333504 hasConcept C501593827 @default.
- W2091333504 hasConcept C523546767 @default.
- W2091333504 hasConcept C54355233 @default.
- W2091333504 hasConcept C547475151 @default.
- W2091333504 hasConcept C55493867 @default.
- W2091333504 hasConcept C71924100 @default.
- W2091333504 hasConcept C86803240 @default.
- W2091333504 hasConcept C89423630 @default.
- W2091333504 hasConcept C98274493 @default.
- W2091333504 hasConceptScore W2091333504C104317684 @default.
- W2091333504 hasConceptScore W2091333504C150903083 @default.
- W2091333504 hasConceptScore W2091333504C185592680 @default.
- W2091333504 hasConceptScore W2091333504C207001950 @default.
- W2091333504 hasConceptScore W2091333504C2777058267 @default.
- W2091333504 hasConceptScore W2091333504C2777637488 @default.
- W2091333504 hasConceptScore W2091333504C2778049240 @default.
- W2091333504 hasConceptScore W2091333504C2778512257 @default.
- W2091333504 hasConceptScore W2091333504C2778910516 @default.
- W2091333504 hasConceptScore W2091333504C2781276175 @default.
- W2091333504 hasConceptScore W2091333504C3019249092 @default.
- W2091333504 hasConceptScore W2091333504C501593827 @default.
- W2091333504 hasConceptScore W2091333504C523546767 @default.
- W2091333504 hasConceptScore W2091333504C54355233 @default.
- W2091333504 hasConceptScore W2091333504C547475151 @default.
- W2091333504 hasConceptScore W2091333504C55493867 @default.
- W2091333504 hasConceptScore W2091333504C71924100 @default.
- W2091333504 hasConceptScore W2091333504C86803240 @default.
- W2091333504 hasConceptScore W2091333504C89423630 @default.
- W2091333504 hasConceptScore W2091333504C98274493 @default.
- W2091333504 hasIssue "6" @default.
- W2091333504 hasLocation W20913335041 @default.
- W2091333504 hasLocation W20913335042 @default.
- W2091333504 hasOpenAccess W2091333504 @default.
- W2091333504 hasPrimaryLocation W20913335041 @default.
- W2091333504 hasRelatedWork W1896852360 @default.
- W2091333504 hasRelatedWork W2015401200 @default.
- W2091333504 hasRelatedWork W2028403515 @default.
- W2091333504 hasRelatedWork W2039859453 @default.
- W2091333504 hasRelatedWork W2110201520 @default.
- W2091333504 hasRelatedWork W2120111593 @default.
- W2091333504 hasRelatedWork W2124899117 @default.
- W2091333504 hasRelatedWork W2355331393 @default.
- W2091333504 hasRelatedWork W2387892627 @default.
- W2091333504 hasRelatedWork W2394104505 @default.
- W2091333504 hasVolume "35" @default.
- W2091333504 isParatext "false" @default.
- W2091333504 isRetracted "false" @default.
- W2091333504 magId "2091333504" @default.
- W2091333504 workType "article" @default.