FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091337862> ?p ?o ?g. }

• W2091337862 endingPage "218" @default.
• W2091337862 startingPage "212" @default.
• W2091337862 abstract "Diarrhea in infants and children is a major health hazard worldwide. Certain toxigenic diarrheas occur more commonly and are manifested more severely during the neonatal period. We have previously studied the regulation of cholera toxin-induced secretion in animal models during development. In those studies we have shown that cholera toxin stimulates a much greater secretion by immature compared with mature small intestine, and the mechanism appears to be an up-regulation of postreceptor signal transduction molecules (adenyl cyclase and Gsalpha) leading to an elevated cAMP level. In this study, using experimental models of human intestinal development (fetal cell lines, a micro-Ussing chamber, organ cultures, and fetal intestinal xenograft transplants), we provide preliminary evidence that cholera toxin induces an enhanced secretion mediated in part by a developmental up-regulation of the cAMP response in immature versus mature human small intestine. Additional studies are needed, however, to further define whether other developmental events (e.g. receptor expression) also regulate cholera toxin-enterocyte-enhanced interaction. Nonetheless, this approach to determining the role of development in the pathophysiology of cholera in infants may help in strategies to prevent and treat this condition and other age-related intestinal infectious diseases." @default.
• W2091337862 created "2016-06-24" @default.
• W2091337862 creator A5008261726 @default.
• W2091337862 creator A5013298818 @default.
• W2091337862 creator A5014760553 @default.
• W2091337862 creator A5015142199 @default.
• W2091337862 creator A5044356368 @default.
• W2091337862 date "2003-08-01" @default.
• W2091337862 modified "2023-10-18" @default.
• W2091337862 title "Development of Microbial-Human Enterocyte Interaction: Cholera Toxin" @default.
• W2091337862 cites W1408833436 @default.
• W2091337862 cites W1635782272 @default.
• W2091337862 cites W1871122671 @default.
• W2091337862 cites W1928775315 @default.
• W2091337862 cites W1982683257 @default.
• W2091337862 cites W1987745937 @default.
• W2091337862 cites W1989647615 @default.
• W2091337862 cites W1990967045 @default.
• W2091337862 cites W2017428327 @default.
• W2091337862 cites W2021144508 @default.
• W2091337862 cites W2027442973 @default.
• W2091337862 cites W2058539599 @default.
• W2091337862 cites W2075096051 @default.
• W2091337862 cites W2085979316 @default.
• W2091337862 cites W2091479452 @default.
• W2091337862 cites W2098498572 @default.
• W2091337862 cites W2106992298 @default.
• W2091337862 cites W2108342223 @default.
• W2091337862 cites W2125380985 @default.
• W2091337862 cites W2147818871 @default.
• W2091337862 cites W2151502111 @default.
• W2091337862 cites W222506362 @default.
• W2091337862 cites W2940365551 @default.
• W2091337862 cites W74593414 @default.
• W2091337862 doi "https://doi.org/10.1203/01.pdr.0000074974.21797.83" @default.
• W2091337862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12736381" @default.
• W2091337862 hasPublicationYear "2003" @default.
• W2091337862 type Work @default.
• W2091337862 sameAs 2091337862 @default.
• W2091337862 citedByCount "13" @default.
• W2091337862 countsByYear W20913378622013 @default.
• W2091337862 countsByYear W20913378622015 @default.
• W2091337862 crossrefType "journal-article" @default.
• W2091337862 hasAuthorship W2091337862A5008261726 @default.
• W2091337862 hasAuthorship W2091337862A5013298818 @default.
• W2091337862 hasAuthorship W2091337862A5014760553 @default.
• W2091337862 hasAuthorship W2091337862A5015142199 @default.
• W2091337862 hasAuthorship W2091337862A5044356368 @default.
• W2091337862 hasBestOaLocation W20913378621 @default.
• W2091337862 hasConcept C134018914 @default.
• W2091337862 hasConcept C170493617 @default.
• W2091337862 hasConcept C203014093 @default.
• W2091337862 hasConcept C2777006276 @default.
• W2091337862 hasConcept C2777047711 @default.
• W2091337862 hasConcept C2777367657 @default.
• W2091337862 hasConcept C2777882243 @default.
• W2091337862 hasConcept C2778643871 @default.
• W2091337862 hasConcept C2779604457 @default.
• W2091337862 hasConcept C2780722889 @default.
• W2091337862 hasConcept C49039625 @default.
• W2091337862 hasConcept C523546767 @default.
• W2091337862 hasConcept C54355233 @default.
• W2091337862 hasConcept C62478195 @default.
• W2091337862 hasConcept C86803240 @default.
• W2091337862 hasConcept C89423630 @default.
• W2091337862 hasConcept C95444343 @default.
• W2091337862 hasConceptScore W2091337862C134018914 @default.
• W2091337862 hasConceptScore W2091337862C170493617 @default.
• W2091337862 hasConceptScore W2091337862C203014093 @default.
• W2091337862 hasConceptScore W2091337862C2777006276 @default.
• W2091337862 hasConceptScore W2091337862C2777047711 @default.
• W2091337862 hasConceptScore W2091337862C2777367657 @default.
• W2091337862 hasConceptScore W2091337862C2777882243 @default.
• W2091337862 hasConceptScore W2091337862C2778643871 @default.
• W2091337862 hasConceptScore W2091337862C2779604457 @default.
• W2091337862 hasConceptScore W2091337862C2780722889 @default.
• W2091337862 hasConceptScore W2091337862C49039625 @default.
• W2091337862 hasConceptScore W2091337862C523546767 @default.
• W2091337862 hasConceptScore W2091337862C54355233 @default.
• W2091337862 hasConceptScore W2091337862C62478195 @default.
• W2091337862 hasConceptScore W2091337862C86803240 @default.
• W2091337862 hasConceptScore W2091337862C89423630 @default.
• W2091337862 hasConceptScore W2091337862C95444343 @default.
• W2091337862 hasIssue "2" @default.
• W2091337862 hasLocation W20913378621 @default.
• W2091337862 hasLocation W20913378622 @default.
• W2091337862 hasOpenAccess W2091337862 @default.
• W2091337862 hasPrimaryLocation W20913378621 @default.
• W2091337862 hasRelatedWork W1758049144 @default.
• W2091337862 hasRelatedWork W177855680 @default.
• W2091337862 hasRelatedWork W1914790964 @default.
• W2091337862 hasRelatedWork W2003754195 @default.
• W2091337862 hasRelatedWork W2017576079 @default.
• W2091337862 hasRelatedWork W2042220177 @default.
• W2091337862 hasRelatedWork W2103829098 @default.
• W2091337862 hasRelatedWork W2121963792 @default.
• W2091337862 hasRelatedWork W2122462340 @default.
• W2091337862 hasRelatedWork W2409295924 @default.

• next