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• W2091340078 abstract "The time course of the response to prolonged application of acetylcholine in mesenteric arteries from stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY) was compared. Only a relaxing response, which was blocked by Nω-nitro-l-arginine (l-NOARG), was observed after the prolonged application of a low concentration of acetylcholine (10−8 M) in both preparations; the response was impaired in SHRSP preparations. Prolonged application of a high concentration of acetylcholine (10−5 M) induced a second contractile response after a first relaxing response in SHRSP preparations under basal conditions and in WKY preparations in the presence of l-NOARG. This contractile response was attenuated by indomethacin. In the presence of a combination of apamin and charybdotoxin, the relaxing response to the high concentration of acetylcholine was reduced and a contractile response, which was abolished by indomethacin, appeared. In the presence of all of these blockers, a contractile response, which was blocked by cyclo(d-α-aspartyl-l-propyl-d-valyl-l-leucyl-d-tryptophyl) (BQ-123), was observed in preparations from WKY but not in preparations from SHRSP. Results indicate that prolonged application of acetylcholine in rat mesenteric arteries induces the release of endothelium-derived relaxing, contracting, hyperpolarizing factors and endothelin-1, and that the mode of action differs between preparations from WKY and SHRSP." @default.
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• W2091340078 date "2001-06-01" @default.
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• W2091340078 title "Factors involved in the time course of response to acetylcholine in mesenteric arteries from spontaneously hypertensive rats" @default.
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• W2091340078 doi "https://doi.org/10.1016/s0014-2999(01)01081-0" @default.
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