FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091342622> ?p ?o ?g. }

• W2091342622 endingPage "1018" @default.
• W2091342622 startingPage "1012" @default.
• W2091342622 abstract "Although the number of mesenchymal stem cells (MSC) in the bone marrow is sufficient to maintain skeletal homeostasis, in osteopenic pathology, aggravated osteoclast activity or insufficient osteoblast numbers ensue, affecting normal bone remodeling. Most of the currently available therapies are anti-resorptive with limited osteogenic potential. Since mobilization of stem/progenitors from the BM is a prerequisite for their participation in tissue repair, amplification of endogenous stem cells may provide an alternative approach in these conditions. The present study determined the potential of MSC mobilization in vivo, using combinations of different growth factors with the CXCR4 antagonist, AMD3100, in a mouse model of segmental bone defect. Results indicated that among several factors tested IGF1 had maximum proliferative ability of MSC in vitro. Results of the in vivo studies indicated that the combination of IGF1 and AMD3100 provided significant augmentation of bone growth as determined by DXA, micro-CT and histomorphometry in mice bearing segmental fractures. Further, characterization of MSC isolated from mice treated with IGF1 and AMD3100 indicated Akt/PI3K, MEK1/2-Erk1/2 and smad2/3 as key signaling pathways mediating this effect. These data indicate the potential of in vivo stem cell mobilization as a novel alternative for bone healing." @default.
• W2091342622 created "2016-06-24" @default.
• W2091342622 creator A5017420879 @default.
• W2091342622 creator A5080151888 @default.
• W2091342622 date "2012-04-01" @default.
• W2091342622 modified "2023-09-25" @default.
• W2091342622 title "Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defect" @default.
• W2091342622 cites W1533598873 @default.
• W2091342622 cites W1586474677 @default.
• W2091342622 cites W1631250427 @default.
• W2091342622 cites W1967217261 @default.
• W2091342622 cites W1977437881 @default.
• W2091342622 cites W1984548551 @default.
• W2091342622 cites W1991392063 @default.
• W2091342622 cites W1997097878 @default.
• W2091342622 cites W1997405293 @default.
• W2091342622 cites W2010152981 @default.
• W2091342622 cites W2013743258 @default.
• W2091342622 cites W2014648588 @default.
• W2091342622 cites W2019381460 @default.
• W2091342622 cites W2025138472 @default.
• W2091342622 cites W2026851205 @default.
• W2091342622 cites W2039707890 @default.
• W2091342622 cites W2045835452 @default.
• W2091342622 cites W2048121649 @default.
• W2091342622 cites W2049287362 @default.
• W2091342622 cites W2052350491 @default.
• W2091342622 cites W2058554403 @default.
• W2091342622 cites W2079090941 @default.
• W2091342622 cites W2080463244 @default.
• W2091342622 cites W2080741216 @default.
• W2091342622 cites W2085117081 @default.
• W2091342622 cites W2097577343 @default.
• W2091342622 cites W2104898886 @default.
• W2091342622 cites W2107259575 @default.
• W2091342622 cites W2113777483 @default.
• W2091342622 cites W2129680615 @default.
• W2091342622 cites W2133496200 @default.
• W2091342622 cites W2137491282 @default.
• W2091342622 cites W2138822815 @default.
• W2091342622 cites W2144456609 @default.
• W2091342622 cites W2145349151 @default.
• W2091342622 cites W2147156629 @default.
• W2091342622 cites W2155907836 @default.
• W2091342622 cites W2163065691 @default.
• W2091342622 cites W2167301573 @default.
• W2091342622 cites W2168783417 @default.
• W2091342622 cites W2416445965 @default.
• W2091342622 cites W98258303 @default.
• W2091342622 doi "https://doi.org/10.1016/j.bone.2012.01.027" @default.
• W2091342622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3339043" @default.
• W2091342622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22342795" @default.
• W2091342622 hasPublicationYear "2012" @default.
• W2091342622 type Work @default.
• W2091342622 sameAs 2091342622 @default.
• W2091342622 citedByCount "94" @default.
• W2091342622 countsByYear W20913426222012 @default.
• W2091342622 countsByYear W20913426222013 @default.
• W2091342622 countsByYear W20913426222014 @default.
• W2091342622 countsByYear W20913426222015 @default.
• W2091342622 countsByYear W20913426222016 @default.
• W2091342622 countsByYear W20913426222017 @default.
• W2091342622 countsByYear W20913426222018 @default.
• W2091342622 countsByYear W20913426222019 @default.
• W2091342622 countsByYear W20913426222020 @default.
• W2091342622 countsByYear W20913426222021 @default.
• W2091342622 countsByYear W20913426222022 @default.
• W2091342622 countsByYear W20913426222023 @default.
• W2091342622 crossrefType "journal-article" @default.
• W2091342622 hasAuthorship W2091342622A5017420879 @default.
• W2091342622 hasAuthorship W2091342622A5080151888 @default.
• W2091342622 hasBestOaLocation W20913426222 @default.
• W2091342622 hasConcept C105702510 @default.
• W2091342622 hasConcept C126322002 @default.
• W2091342622 hasConcept C142724271 @default.
• W2091342622 hasConcept C150903083 @default.
• W2091342622 hasConcept C170033053 @default.
• W2091342622 hasConcept C170493617 @default.
• W2091342622 hasConcept C198826908 @default.
• W2091342622 hasConcept C201750760 @default.
• W2091342622 hasConcept C207001950 @default.
• W2091342622 hasConcept C2776033226 @default.
• W2091342622 hasConcept C2780007613 @default.
• W2091342622 hasConcept C28328180 @default.
• W2091342622 hasConcept C71924100 @default.
• W2091342622 hasConcept C8337478 @default.
• W2091342622 hasConcept C86803240 @default.
• W2091342622 hasConcept C95444343 @default.
• W2091342622 hasConceptScore W2091342622C105702510 @default.
• W2091342622 hasConceptScore W2091342622C126322002 @default.
• W2091342622 hasConceptScore W2091342622C142724271 @default.
• W2091342622 hasConceptScore W2091342622C150903083 @default.
• W2091342622 hasConceptScore W2091342622C170033053 @default.
• W2091342622 hasConceptScore W2091342622C170493617 @default.
• W2091342622 hasConceptScore W2091342622C198826908 @default.
• W2091342622 hasConceptScore W2091342622C201750760 @default.
• W2091342622 hasConceptScore W2091342622C207001950 @default.
• W2091342622 hasConceptScore W2091342622C2776033226 @default.

• next