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- W2091343165 abstract "Abstract The isolated perfused rat brain was used for a comparative study of the effects of thiopental (0.2 mM), hexobarbital (0.2 mM), γ-hydroxybutyric acid (4 mM) and ketamine (0.05 mM) on cerebral energy metabolism. After a perfusion period of 30 min the brain levels of high-energy phosphates, as well as those of substrates and metabolites of the glycolytic pathway were measured spectrophotometrically. All drugs tested caused an increase in cerebral P-creatine. Furthermore, after perfusion with the barbiturates, or γ-hydroxybutyric acid, increased levels of glycogen and glucose, and decreased levels of pyruvate and lactate were measured. After ketamine perfusion, however, the glycogen and glucose levels tended to be diminished. Doubling the glucose concentration in the perfusion medium led to a marked increase in brain glucose, which after anesthesia with thiopental increased even further." @default.
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- W2091343165 date "1975-09-01" @default.
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- W2091343165 title "Energy metabolism of the isolated perfused rat brain as influenced by anesthetics" @default.
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- W2091343165 doi "https://doi.org/10.1016/0006-2952(75)90082-9" @default.
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