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- W2091344206 abstract "The body distribution of electrically charged dextran derivatives was investigated after intravenous administration of 125I-labeled dextrans. The effects of the charge density and molecular weight of dextran derivatives on their half-lives in the circulation and organ distribution were pharmacokinetically analyzed. The introduction of negative charges into the dextran molecule prolonged its half-life in the circulation. This trend became more marked with increasing molecular weight of the dextran, however, its half-life was reduced by derivatization with cationic diethylaminoethyl groups. The cationized dextran accumulated in the liver more significantly than the anionized and original dextrans. For example, approx. 10% substitution of dextran with the diethylaminoethyl group was sufficient to enhance the accumulation of dextran in the liver and spleen, but no effect of cationic derivatization was observed for the distribution in other tissues." @default.
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- W2091344206 date "1995-01-01" @default.
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- W2091344206 title "Body distribution of dextran derivatives with electric charges after intravenous administration" @default.
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- W2091344206 doi "https://doi.org/10.1016/0378-5173(94)00189-c" @default.
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