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- W2091350218 endingPage "14887" @default.
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- W2091350218 abstract "Significance To select for novel monoclonal antibodies (mAbs) with anticancer activity, an experimental platform was established wherein human breast cancer cells were embedded in 3D collagen matrices and used as an immunogen to generate mAb libraries. Fifteen mAbs capable of inhibiting carcinoma cell growth in vitro were generated. A single function-blocking mAb was selected for further analysis and then validated as a potent inhibitor of carcinoma cell behavior in vivo. The target antigen was identified as the α 2 subunit of the α 2 β 1 integrin, a major type I collagen-binding receptor whose expression was confirmed in tissues of patients with breast cancer. These findings describe a new discovery platform that allows for the rapid selection of function-blocking antibodies and identify α 2 β 1 as a potential target in carcinomatous states." @default.
- W2091350218 created "2016-06-24" @default.
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- W2091350218 date "2014-09-29" @default.
- W2091350218 modified "2023-09-24" @default.
- W2091350218 title "A 3D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies" @default.
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- W2091350218 doi "https://doi.org/10.1073/pnas.1410996111" @default.
- W2091350218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4205646" @default.
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