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- W2091355219 abstract "Distribution of the delta- and epsilon-subspecies of protein kinase C (PKC) in rat central nervous tissues was semiquantitated by an immunoblot analysis. The epsilon-subspecies, which is expressed predominantly in the brain, was abundant in hippocampus and cerebral cortex among rat brain areas, whereas the delta-subspecies, which is expressed ubiquitously in many tissues, showed no significant difference among tissue areas tested. Unlike other subspecies, the delta-subspecies was primarily associated with particulate fractions. Subcellular fractionation analysis revealed that both the epsilon- and delta-subspecies were enriched in the synaptosomal P2 fraction. Treatment with 12-O-tetradecanoyl-phorbol 13-acetate (TPA) induced translocation of the epsilon-subspecies from cytosolic fraction to membrane fraction. In contrast, upon treatment with TPA, the delta-subspecies normally bound to membrane fraction was released into cytosol." @default.
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- W2091355219 date "1994-05-01" @default.
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- W2091355219 title "Protein kinase C δ- and ϵ-subspecies in rat central nervous tissue; differential distribution and phorbol ester-induced redistribution in synaptosomes" @default.
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- W2091355219 doi "https://doi.org/10.1016/0168-0102(94)90047-7" @default.
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