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• W2091371822 abstract "RAS genes, predominantly N-RAS and K-RAS, have been implicated in the pathogenesis of acute myeloid leukemia (AML), due to activating RAS mutations detectable in approximately 20% of AML patients. In the present study, RAS proteins were detected in their activated, GTP-bound form, in AML patients (n = 10) not expressing mutated forms of H-RAS, K-RAS and N-RAS. Further analysis revealed the simultaneous presence of N-RAS and K-RAS proteins in the GTP-bound state in seven out of 10 AML samples. In four out of 10 samples the levels of RAS-GTP were comparable to an AML cell line (TF-1) with an activating N-RAS mutation (Q61P). The detection of RAS-GTP in AML patients without RAS mutations further supports a functional role of RAS proteins in the pathogenesis of AML and may explain the observed effects of RAS inhibitors in some AML patients in the absence of activating RAS mutations." @default.
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• W2091371822 date "2006-01-01" @default.
• W2091371822 modified "2023-09-26" @default.
• W2091371822 title "Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activatingRASmutations" @default.
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• W2091371822 doi "https://doi.org/10.1080/10428190600565925" @default.
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