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- W2091378419 abstract "Cytochrome P4502D6 (CYP2D6) is the major target of liverkidney-microsome type-1 (LKM-1) antibodies associated with autoimmune hepatitis type 2 (AIH2) [1]. This subtype of autoimmune hepatitis is characterized histologically by severe mononuclear cell infiltration of the hepatic portal tracts and parenchymal necrosis, with early progression to cirrhosis despite treatment. The presentation of AIH2 is heterogeneous, from a variety of mild, nonspecific symptoms, that develop insidiously, to profound jaundice with markedly elevated serum transaminases, and sometimes fulminant hepatitis. Patients are predominantly female, with children and young adults being at highest risk [2]." @default.
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- W2091378419 date "1997-06-01" @default.
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- W2091378419 title "Cytochrome P4502D6: understanding an autoantigen" @default.
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- W2091378419 doi "https://doi.org/10.1046/j.1365-2249.1997.4131311.x" @default.
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