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- W2091401295 abstract "To evaluate the indications and the results of a 2104 consecutive genetic amniocentesis in a single prenatal centre. To define the maternal age over which amniocentesis should be offered to women with a normal level II scan. Retrospective study over a period of 3 years. 12300 prenatal ultrasound examinations and 2104 amniocentesis were performed between 16–22 weeks' gestation. Main indications for amniocentesis were maternal age over 35 1299/2104 (61.73%), positive biochemical markers 268/2104 (12.73%), parental anxiety 205/2104 (9.74%), echogenic intracardiac foci 170/2104 (8.08%), mild hydronephrosis 38/2104 (1.81%), nuchal fold greater than 6 mm 29 (1.38%), echogenic bowel 23/2104 (1.09%), mild ventriculomegaly 10 (0.48%), IUGR 11 (0.52%), severe fetal malformations 34/2104 (1.62%) and others. Totally 45 (2.13%) abnormal karyotypes were found whereas 27 trisomy 21 cases (1.28%), 7 trisomy 18 cases (0.33). Severe malformations and increased nuchal fold were the most reliable indication for amniocentesis (aneuploidy rate: 37.5% and 24.1%). Second trimester serum screening, maternal anxiety and minor sonographic markers were rather poor indicators of fetal karyotype abnormalities (1.19%, 0.0% and 1.02% abnormal karyotype respectively). Maternal age when used as a sole indication for amniocentesis had an aneuploidy detection rate of 1.6%. According to these data women over 37 should be offered amniocentesis in a normal level II scan. Fetal malformations and increased nuchal fold are mainly the factors contributing to the prenatal detection of abnormal karyotype. Women younger than 37 years-old should not be offered amniocentesis in a normal level II scan. Detailed counselling is warranted prior to genetic amniocentesis, especially in cases of increased maternal anxiety and the presence of minor sonographic markers." @default.
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- W2091401295 date "2004-08-01" @default.
- W2091401295 modified "2023-09-26" @default.
- W2091401295 title "P10.29: Aneuploidy rates in 2104 consecutive amniocentesis in a single referral unit. Reappraisal of amniocentesis indications" @default.
- W2091401295 doi "https://doi.org/10.1002/uog.1525" @default.
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