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• W2091403676 abstract "The extremely fast and efficient folding transition (in seconds) of globular proteins led to the search for some unifying principles embedded in the physics of the folding polypeptides. Most of the proposed mechanisms highlight the role of local interactions that stabilize secondary structure elements or a folding nucleus as the starting point of the folding pathways, i.e., a “bottom–up” mechanism. Non-local interactions were assumed either to stabilize the nucleus or lead to the later steps of coalescence of the secondary structure elements. An alternative mechanism was proposed, an “up–down” mechanism in which it was assumed that folding starts with the formation of very few non-local interactions which form closed long loops at the initiation of folding. The possible biological advantage of this mechanism, the “loop hypothesis”, is that the hydrophobic collapse is associated with ordered compactization which reduces the chance for degradation and misfolding. In the present review the experiments, simulations and theoretical consideration that either directly or indirectly support this mechanism are summarized. It is argued that experiments monitoring the time-dependent development of the formation of specifically targeted early-formed sub-domain structural elements, either long loops or secondary structure elements, are necessary. This can be achieved by the time-resolved FRET-based “double kinetics” method in combination with mutational studies. Yet, attempts to improve the time resolution of the folding initiation should be extended down to the sub-microsecond time regime in order to design experiments that would resolve the classes of proteins which first fold by local or non-local interactions." @default.
• W2091403676 created "2016-06-24" @default.
• W2091403676 creator A5022085824 @default.
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• W2091403676 creator A5066543524 @default.
• W2091403676 creator A5082572644 @default.
• W2091403676 creator A5091612932 @default.
• W2091403676 date "2013-04-12" @default.
• W2091403676 modified "2023-10-18" @default.
• W2091403676 title "The loop hypothesis: contribution of early formed specific non-local interactions to the determination of protein folding pathways" @default.
• W2091403676 cites W1493963509 @default.
• W2091403676 cites W1497161759 @default.
• W2091403676 cites W1550166367 @default.
• W2091403676 cites W1964905971 @default.
• W2091403676 cites W1968701666 @default.
• W2091403676 cites W1969163423 @default.
• W2091403676 cites W1970151294 @default.
• W2091403676 cites W1970197953 @default.
• W2091403676 cites W1972117902 @default.
• W2091403676 cites W1974704181 @default.
• W2091403676 cites W1976005460 @default.
• W2091403676 cites W1976025783 @default.
• W2091403676 cites W1976271045 @default.
• W2091403676 cites W1976654525 @default.
• W2091403676 cites W1978033776 @default.
• W2091403676 cites W1978794978 @default.
• W2091403676 cites W1978817612 @default.
• W2091403676 cites W1979748675 @default.
• W2091403676 cites W1980641227 @default.
• W2091403676 cites W1982843071 @default.
• W2091403676 cites W1984148408 @default.
• W2091403676 cites W1986625330 @default.
• W2091403676 cites W1988690429 @default.
• W2091403676 cites W1989300794 @default.
• W2091403676 cites W1992959060 @default.
• W2091403676 cites W1998570065 @default.
• W2091403676 cites W2000531275 @default.
• W2091403676 cites W2000612788 @default.
• W2091403676 cites W2001307761 @default.
• W2091403676 cites W2002439378 @default.
• W2091403676 cites W2005197624 @default.
• W2091403676 cites W2005845431 @default.
• W2091403676 cites W2005865331 @default.
• W2091403676 cites W2006460346 @default.
• W2091403676 cites W2007419082 @default.
• W2091403676 cites W2010556510 @default.
• W2091403676 cites W2010580822 @default.
• W2091403676 cites W2010631370 @default.
• W2091403676 cites W2011109781 @default.
• W2091403676 cites W2011571179 @default.
• W2091403676 cites W2014541368 @default.
• W2091403676 cites W2014546846 @default.
• W2091403676 cites W2016019576 @default.
• W2091403676 cites W2019447526 @default.
• W2091403676 cites W2025231340 @default.
• W2091403676 cites W2026063351 @default.
• W2091403676 cites W2029976015 @default.
• W2091403676 cites W2032306965 @default.
• W2091403676 cites W2033279214 @default.
• W2091403676 cites W2034327581 @default.
• W2091403676 cites W2034669559 @default.
• W2091403676 cites W2037410278 @default.
• W2091403676 cites W2038762649 @default.
• W2091403676 cites W2041481056 @default.
• W2091403676 cites W2044256525 @default.
• W2091403676 cites W2047740474 @default.
• W2091403676 cites W2048236251 @default.
• W2091403676 cites W2049690939 @default.
• W2091403676 cites W2049966629 @default.
• W2091403676 cites W2049994789 @default.
• W2091403676 cites W2055118532 @default.
• W2091403676 cites W2055827177 @default.
• W2091403676 cites W2056460772 @default.
• W2091403676 cites W2059907401 @default.
• W2091403676 cites W2060528711 @default.
• W2091403676 cites W2060792417 @default.
• W2091403676 cites W2061460855 @default.
• W2091403676 cites W2061794650 @default.
• W2091403676 cites W2063870542 @default.
• W2091403676 cites W206478229 @default.
• W2091403676 cites W2069088519 @default.
• W2091403676 cites W2072843928 @default.
• W2091403676 cites W2076430296 @default.
• W2091403676 cites W2076836419 @default.
• W2091403676 cites W2076949662 @default.
• W2091403676 cites W2078362254 @default.
• W2091403676 cites W2078512978 @default.
• W2091403676 cites W2079492386 @default.
• W2091403676 cites W2079673685 @default.
• W2091403676 cites W2079884830 @default.
• W2091403676 cites W2082759836 @default.
• W2091403676 cites W2084156924 @default.
• W2091403676 cites W2087831048 @default.
• W2091403676 cites W2089597488 @default.
• W2091403676 cites W2092637963 @default.
• W2091403676 cites W2094573652 @default.
• W2091403676 cites W2095256420 @default.
• W2091403676 cites W2096933265 @default.

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