FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091420742> ?p ?o ?g. }

• W2091420742 endingPage "349" @default.
• W2091420742 startingPage "339" @default.
• W2091420742 abstract "Follicle-stimulating hormone (FSH) is a pituitary glycoprotein hormone that is comprised of two dissimilar subunits, α and β, encoded by separate genes. We have isolated the gene encoding the β-subunit of rat FSH by screening a rat genomic DNA library by filter hybridization with bovine FSH-β cDNA. Southern blot analysis of rat genomic DNA suggests that there is a single copy of the FSH-β gene per haploid genome in the rat. The nucleotide sequence of the rat FSH-β gene was determined and the amino acid sequence of the subunit was deduced. The gene is composed of three exons and two introns. The predicted amino acid sequence reveals that there is a 20-amino-acid signal peptide followed by a mature protein of 110 amino acid residues. Exons I, II, and III are 36, 187, and 1221 bp, respectively. Intron 1 (640 bp) interrupts the 5′-untranslated (UT) region (61 bp) and intron 2 (approximately 1 kb) interrupts the coding region between amino acid residues +34 and +35. Comparison of the amino acid sequence to those of the human and bovine FSH-β subunits reveals 80% similarity to both species. The CAGY sequence, or the Cys-Ala-Gly-Tyr quartet of amino acids encoded by exon II is present in every other glycoprotein β-subunit sequenced thus far, is altered in rat FSH-β, with the Ala residue replaced by Glu. Primer extension analysis demonstrated that there is a single transcriptional start site. The nucleotide sequence of the 5′-flanking region (1 kb) was determined and compared to the nucleotide sequences of corresponding regions in the bovine and human genes. This analysis revealed that there are three regions in the 5′-flanking region of the rat FSH-β gene that display greater than 80% sequence similarity to regions in the bovine and human genes. The second of these regions also shares similarity to segments within the 5′-flanking regions of the rat α- and LHβ-subunit genes. The characterization of the rat FSH-β gene will enable further study of the regulation of rat FSH using in vitro systems." @default.
• W2091420742 created "2016-06-24" @default.
• W2091420742 creator A5010710629 @default.
• W2091420742 creator A5012399791 @default.
• W2091420742 creator A5022380523 @default.
• W2091420742 creator A5076835766 @default.
• W2091420742 date "1989-06-01" @default.
• W2091420742 modified "2023-09-25" @default.
• W2091420742 title "Isolation and Characterization of the Gene Encoding the β-Subunit of Rat Follicle-Stimulating Hormone" @default.
• W2091420742 cites W147138264 @default.
• W2091420742 cites W1510604115 @default.
• W2091420742 cites W1537080078 @default.
• W2091420742 cites W1552057692 @default.
• W2091420742 cites W1558516755 @default.
• W2091420742 cites W1577701521 @default.
• W2091420742 cites W1580274923 @default.
• W2091420742 cites W1597961406 @default.
• W2091420742 cites W1736071032 @default.
• W2091420742 cites W1964956210 @default.
• W2091420742 cites W1967427723 @default.
• W2091420742 cites W1970609334 @default.
• W2091420742 cites W1970729813 @default.
• W2091420742 cites W1971165489 @default.
• W2091420742 cites W1985801550 @default.
• W2091420742 cites W1989121649 @default.
• W2091420742 cites W1998152163 @default.
• W2091420742 cites W1998984757 @default.
• W2091420742 cites W2006673026 @default.
• W2091420742 cites W2011775394 @default.
• W2091420742 cites W2014669590 @default.
• W2091420742 cites W2024953786 @default.
• W2091420742 cites W2026129188 @default.
• W2091420742 cites W2031192188 @default.
• W2091420742 cites W2031399745 @default.
• W2091420742 cites W2036278502 @default.
• W2091420742 cites W2044648543 @default.
• W2091420742 cites W2054092438 @default.
• W2091420742 cites W2056262098 @default.
• W2091420742 cites W2058915390 @default.
• W2091420742 cites W2058924262 @default.
• W2091420742 cites W2060889469 @default.
• W2091420742 cites W2071999321 @default.
• W2091420742 cites W2074030375 @default.
• W2091420742 cites W2074197262 @default.
• W2091420742 cites W2078119356 @default.
• W2091420742 cites W2078172881 @default.
• W2091420742 cites W2080532845 @default.
• W2091420742 cites W2085131417 @default.
• W2091420742 cites W2085562009 @default.
• W2091420742 cites W2085828113 @default.
• W2091420742 cites W2088560939 @default.
• W2091420742 cites W2090312971 @default.
• W2091420742 cites W2092292088 @default.
• W2091420742 cites W2093943347 @default.
• W2091420742 cites W2094796209 @default.
• W2091420742 cites W2105361613 @default.
• W2091420742 cites W2121080380 @default.
• W2091420742 cites W2138270253 @default.
• W2091420742 cites W2145272878 @default.
• W2091420742 cites W2148866023 @default.
• W2091420742 cites W2158893070 @default.
• W2091420742 cites W2385673887 @default.
• W2091420742 doi "https://doi.org/10.1089/dna.1.1989.8.339" @default.
• W2091420742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2504572" @default.
• W2091420742 hasPublicationYear "1989" @default.
• W2091420742 type Work @default.
• W2091420742 sameAs 2091420742 @default.
• W2091420742 citedByCount "62" @default.
• W2091420742 countsByYear W20914207422013 @default.
• W2091420742 countsByYear W20914207422014 @default.
• W2091420742 countsByYear W20914207422015 @default.
• W2091420742 countsByYear W20914207422016 @default.
• W2091420742 countsByYear W20914207422017 @default.
• W2091420742 countsByYear W20914207422020 @default.
• W2091420742 countsByYear W20914207422022 @default.
• W2091420742 crossrefType "journal-article" @default.
• W2091420742 hasAuthorship W2091420742A5010710629 @default.
• W2091420742 hasAuthorship W2091420742A5012399791 @default.
• W2091420742 hasAuthorship W2091420742A5022380523 @default.
• W2091420742 hasAuthorship W2091420742A5076835766 @default.
• W2091420742 hasConcept C104317684 @default.
• W2091420742 hasConcept C153911025 @default.
• W2091420742 hasConcept C167625842 @default.
• W2091420742 hasConcept C17757408 @default.
• W2091420742 hasConcept C187882448 @default.
• W2091420742 hasConcept C36823959 @default.
• W2091420742 hasConcept C515207424 @default.
• W2091420742 hasConcept C54355233 @default.
• W2091420742 hasConcept C84148353 @default.
• W2091420742 hasConcept C86803240 @default.
• W2091420742 hasConcept C91779695 @default.
• W2091420742 hasConcept C94671646 @default.
• W2091420742 hasConceptScore W2091420742C104317684 @default.
• W2091420742 hasConceptScore W2091420742C153911025 @default.
• W2091420742 hasConceptScore W2091420742C167625842 @default.
• W2091420742 hasConceptScore W2091420742C17757408 @default.
• W2091420742 hasConceptScore W2091420742C187882448 @default.
• W2091420742 hasConceptScore W2091420742C36823959 @default.

• next