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• W2091430115 abstract "To determine if spinal prostaglandins (PG) contribute to tactile allodynia, male, Sprague–Dawley rats were fitted with either intrathecal (i.t.) microdialysis or drug delivery catheters 3 days before tight ligation of the left lumber 5/6 spinal nerves. Paw withdrawal thresholds (PWT) were determined using von Frey filaments. Ligated rats developed tactile allodynia within 24 h, as evidenced by a decrease in PWT in the affected hindpaw (<4 g vs. >15 g control). Sham-operated controls were unchanged from baseline (>15 g). Allodynia was also characterized by a significant increase in the evoked release of PGE2. Thus, brushing the plantar surface of the affected hindpaw with a cotton-tipped applicator, 5 days postligation, increased the [PGE2]dialysate to 199±34% of the prestimulus control period. In contrast, brushing had no detectable effect on release before surgery or in sham-operated animals. Basal release (no brushing) was similar before and after surgery (sham-operated and ligated rats). In a separate group of rats and beginning 2 days after ligation, the acute i.t. injection of S(+)-ibuprofen, SC-51322, SC-236, or SC-560 significantly reversed allodynia (maximum effect=69±9, 66±6, 57±4, 20±5%, respectively). R(−)-ibuprofen or vehicle were without effect. The results of this study suggest that: (a) spinal PG synthesis and allodynia-like behaviour are triggered by normally innocuous brushing after spinal nerve ligation; (b) pharmacological disruption of this cascade significantly reverses allodynia; (c) COX-2 is the relevant isozyme; and (d) the PG effect is mediated by spinal EP receptors." @default.
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• W2091430115 date "2003-01-01" @default.
• W2091430115 modified "2023-09-26" @default.
• W2091430115 title "Spinal nerve injury activates prostaglandin synthesis in the spinal cord that contributes to early maintenance of tactile allodynia" @default.
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• W2091430115 doi "https://doi.org/10.1016/s0304-3959(02)00322-6" @default.
• W2091430115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12507708" @default.
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