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- W2091434426 abstract "Clozapine is an atypical neuroleptic with two clinical advantages: it may improve otherwise treatment-resistant schizophrenic patients, and it does not induce extrapyramidal side effects or tardive dyskinesia. Pharmacologically, clozapine is a broad-spectrum neuroleptic that binds to several receptors (dopamine, noradrenaline, serotonin, histamine, and acetylcholine) but which has an exeptionally low binding to D-2 dopamine receptors and a relatively high binding to D-1 receptors as compared with traditional neuroleptics such as halo-peridol. Several controlled clinical trials have demonstrated that, compared with traditional neuroleptics, clozapine is a superior antipsychotic drug in the treatment of severe therapy-resistant schizophrenic patients. In doses up to 600 mg/day no extrapyramidal symptoms or tardive dyskinesia is seen, only some slowing of movements and reduced facial expression. Other side effects include sedation, hypersalivation, orthostatism, tachycardia, anticholinergic symptoms (especia..." @default.
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- W2091434426 date "1990-01-01" @default.
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- W2091434426 title "Klozapin. Status 1989" @default.
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- W2091434426 doi "https://doi.org/10.3109/08039489009096566" @default.
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