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- W2091438178 abstract "Purpose: To determine aqueous humor concentrations of brimonidine given the following ophthalmic formulations in female New Zealand White Rabbits: (1) BAK-preserved brimonidine tartrate 0.20% at a pH of 6.4; (2) BAK-preserved brimonidine tartrate 0.15% at a pH of 6.4, and (3) Purite®-preserved brimonidine tartrate 0.15% at a pH of 7.3. Methods: Eighteen (18) animals were given a 35-μL drop of formulation into each eye. Aqueous humor samples were collected at 9 time points over 8 hours. Brimonidine concentrations were quantified using LC-MS/MS. Results: The Cmax was achieved between 0.33–0.67 hours postdosing for all 3 formulations. Mean Cmax after Purite-preserved brimonidine tartrate 0.15% was 88% higher than that after BAK-preserved brimonidine tartrate 0.15% (p = 0.040), and 44% higher than that after BAK-preserved brimonidine tartrate 0.20% (p = 0.0784). AUC0–3 hr values were comparable for all 3 formulations. Conclusions : Purite-preserved brimonidine tartrate 0.15% produced higher peak concentrations than BAK-preserved brimonidine tartrate 0.15%. It also had a concentration that was comparable to BAK-preserved brimonidine tartrate 0.20%. The differences in safety may result from the change in preservative." @default.
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- W2091438178 date "2004-08-01" @default.
- W2091438178 modified "2023-09-27" @default.
- W2091438178 title "Effects of the Preservative Purite<sup>®</sup> on the Bioavailability of Brimonidine in the Aqueous Humor of Rabbits" @default.
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- W2091438178 doi "https://doi.org/10.1089/1080768041725326" @default.
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