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• W2091439684 abstract "Abstract A triple mutant of an esterase from Pseudomonas fluorescens (PFE) that was created by directed evolution exhibited high enantioselectivity ( E =89) in a kinetic resolution and yielded the building block ( S )‐but‐3‐yn‐2‐ol. Surprisingly, a mutation close to the active site caused the formation of inclusion bodies, but remote mutations were found to be responsible for the high selectivity. Back mutations gave a variant (double mutant PFE Ile76Val/Val175Ala) that showed excellent selectivity ( E =96) and activity (20 min for 50 % conversion, which corresponds to 1.25 U per mg of protein)." @default.
• W2091439684 created "2016-06-24" @default.
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• W2091439684 date "2006-04-26" @default.
• W2091439684 modified "2023-10-16" @default.
• W2091439684 title "Directed Evolution of an Esterase from Pseudomonas fluorescens Yields a Mutant with Excellent Enantioselectivity and Activity for the Kinetic Resolution of a Chiral Building Block" @default.
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• W2091439684 doi "https://doi.org/10.1002/cbic.200500546" @default.
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• W2091439684 hasPublicationYear "2006" @default.
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