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• W2091439969 abstract "RNA molecules that are assembled from the four standard nucleotides contain a limited number of chemical functional groups, a characteristic that is generally thought to restrict the potential for catalysis by ribozymes. Although polypeptides carry a wider range of functional groups, many contemporary protein-based enzymes employ coenzymes to augment their capabilities. The coenzymes possess additional chemical moieties that can participate directly in catalysis and thereby enhance catalytic function. In this work, we demonstrate a mechanism by which ribozymes can supplement their limited repertoire of functional groups through RNA-catalyzed incorporation of various coenzymes and coenzyme analogues. The group I ribozyme of Tetrahymena thermophila normally mediates a phosphoester transfer reaction that results in the covalent attachment of guanosine to the ribozyme. Here, a shortened version of the ribozyme is shown to catalyze the self-incorporation of coenzymes and coenzyme analogues, such as NAD+ and dephosphorylated CoA-SH. Similar ribozyme activities may have played an important role in the “RNA world,” when RNA enzymes are thought to have maintained a complex metabolism in the absence of proteins and would have benefited from the inclusion of additional functional groups." @default.
• W2091439969 created "2016-06-24" @default.
• W2091439969 creator A5058375820 @default.
• W2091439969 creator A5064029544 @default.
• W2091439969 date "1995-06-01" @default.
• W2091439969 modified "2023-10-15" @default.
• W2091439969 title "Self-Incorporation of coenzymes by ribozymes" @default.
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• W2091439969 doi "https://doi.org/10.1007/bf00160500" @default.
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