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- W2091442331 abstract "Folinic acid rescue started 42–48 h after the start of MTX resulted in toxicity after doses of more than 1 g/m MTX except when serum levels remained low at 24, 30, and 36 h [3]. The fear that ‘over rescue’ constitutes a problem in the clinically relevant dose range has been found to be baseless and can now be ignored as a reason to reduce folinic acid dosage [5]. These data were not available to the authors when this protocol was designed but should be taken to heart when subsequent studies are being developed. We suspect that this is even more of a problem with patients such as those studied here since it would be expected that infants will be at a greater risk than older children from inadequate rescue and that fluid collections with third spacing will increase the danger of toxicity due to the delayed MTX excretion." @default.
- W2091442331 created "2016-06-24" @default.
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- W2091442331 date "2015-02-12" @default.
- W2091442331 modified "2023-10-16" @default.
- W2091442331 title "Delayed methotrexate excretion in infants and young children with central nervous system tumors and postoperative fluid collections" @default.
- W2091442331 cites W2033095244 @default.
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- W2091442331 doi "https://doi.org/10.1007/s00280-015-2684-0" @default.
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