Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091455840> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2091455840 endingPage "46" @default.
- W2091455840 startingPage "32" @default.
- W2091455840 abstract "A method for the noninvasive, quantitative determination of regional cerebral blood flow (rCBF) in small laboratory animals, such as the rat, is described. The change in magnetic susceptibility in the vicinity of brain capillaries evoked by iv infusion of Gd(DTPA), a paramagnetic agent not crossing the blood-brain barrier, is detected as an attenuation of the 1H signal in T2-weighted MRI sequences. The reduction of the MR signal intensity after 1 or 2 min of Gd(DTPA) infusion correlates well (r > 0.95) with the rCBF values obtained using the well-established [14C] iodoantipyrine method. At a slice thickness of 3 mm, the pixel size typically is 0.15 × 0.5 mm2. The clearance rate of Gd(DTPA) from blood allows repeated measurements of CBF to be made using this technique approximately every 30 min. The experimental results obtained in normal and ischemic rat brain have been rationalized within the frame of a two-compartment model, allowing the definition of optimal experimental conditions for a given CBF: for normal and reduced CBF values (<150 ml/100 g/min) the reduction in MR signal intensity, measured after 1 or 2 min of Gd(DTPA) infusion, correlates closely with the CBF. However, for CBF values<150 ml/100g/min, a more reliable parameter would be the time constant of the MR signal attenuation during the infusion. © 1991 Academic Press, Inc." @default.
- W2091455840 created "2016-06-24" @default.
- W2091455840 creator A5048109297 @default.
- W2091455840 creator A5067230448 @default.
- W2091455840 date "1991-11-01" @default.
- W2091455840 modified "2023-09-29" @default.
- W2091455840 title "Noninvasive determination of regional cerebral blood flow in rats using dynamic imaging with Gd(DTPA)" @default.
- W2091455840 cites W1964044440 @default.
- W2091455840 cites W1968905493 @default.
- W2091455840 cites W1979637318 @default.
- W2091455840 cites W1988143535 @default.
- W2091455840 cites W2007326427 @default.
- W2091455840 cites W2017009049 @default.
- W2091455840 cites W2018121672 @default.
- W2091455840 cites W2113352804 @default.
- W2091455840 cites W2124913096 @default.
- W2091455840 cites W2139794744 @default.
- W2091455840 cites W2310907465 @default.
- W2091455840 doi "https://doi.org/10.1002/mrm.1910220105" @default.
- W2091455840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1798393" @default.
- W2091455840 hasPublicationYear "1991" @default.
- W2091455840 type Work @default.
- W2091455840 sameAs 2091455840 @default.
- W2091455840 citedByCount "29" @default.
- W2091455840 countsByYear W20914558402013 @default.
- W2091455840 countsByYear W20914558402021 @default.
- W2091455840 crossrefType "journal-article" @default.
- W2091455840 hasAuthorship W2091455840A5048109297 @default.
- W2091455840 hasAuthorship W2091455840A5067230448 @default.
- W2091455840 hasConcept C120665830 @default.
- W2091455840 hasConcept C121332964 @default.
- W2091455840 hasConcept C126322002 @default.
- W2091455840 hasConcept C126838900 @default.
- W2091455840 hasConcept C143409427 @default.
- W2091455840 hasConcept C157767197 @default.
- W2091455840 hasConcept C158846371 @default.
- W2091455840 hasConcept C178853913 @default.
- W2091455840 hasConcept C184652730 @default.
- W2091455840 hasConcept C185592680 @default.
- W2091455840 hasConcept C199360897 @default.
- W2091455840 hasConcept C2779843651 @default.
- W2091455840 hasConcept C2989005 @default.
- W2091455840 hasConcept C41008148 @default.
- W2091455840 hasConcept C42219234 @default.
- W2091455840 hasConcept C46141821 @default.
- W2091455840 hasConcept C62520636 @default.
- W2091455840 hasConcept C71924100 @default.
- W2091455840 hasConcept C93038891 @default.
- W2091455840 hasConceptScore W2091455840C120665830 @default.
- W2091455840 hasConceptScore W2091455840C121332964 @default.
- W2091455840 hasConceptScore W2091455840C126322002 @default.
- W2091455840 hasConceptScore W2091455840C126838900 @default.
- W2091455840 hasConceptScore W2091455840C143409427 @default.
- W2091455840 hasConceptScore W2091455840C157767197 @default.
- W2091455840 hasConceptScore W2091455840C158846371 @default.
- W2091455840 hasConceptScore W2091455840C178853913 @default.
- W2091455840 hasConceptScore W2091455840C184652730 @default.
- W2091455840 hasConceptScore W2091455840C185592680 @default.
- W2091455840 hasConceptScore W2091455840C199360897 @default.
- W2091455840 hasConceptScore W2091455840C2779843651 @default.
- W2091455840 hasConceptScore W2091455840C2989005 @default.
- W2091455840 hasConceptScore W2091455840C41008148 @default.
- W2091455840 hasConceptScore W2091455840C42219234 @default.
- W2091455840 hasConceptScore W2091455840C46141821 @default.
- W2091455840 hasConceptScore W2091455840C62520636 @default.
- W2091455840 hasConceptScore W2091455840C71924100 @default.
- W2091455840 hasConceptScore W2091455840C93038891 @default.
- W2091455840 hasIssue "1" @default.
- W2091455840 hasLocation W20914558401 @default.
- W2091455840 hasLocation W20914558402 @default.
- W2091455840 hasOpenAccess W2091455840 @default.
- W2091455840 hasPrimaryLocation W20914558401 @default.
- W2091455840 hasRelatedWork W154739905 @default.
- W2091455840 hasRelatedWork W2048291758 @default.
- W2091455840 hasRelatedWork W2149049977 @default.
- W2091455840 hasRelatedWork W2363584979 @default.
- W2091455840 hasRelatedWork W2748952813 @default.
- W2091455840 hasRelatedWork W2899084033 @default.
- W2091455840 hasRelatedWork W3099308643 @default.
- W2091455840 hasRelatedWork W3118845804 @default.
- W2091455840 hasRelatedWork W4321371163 @default.
- W2091455840 hasRelatedWork W4386702643 @default.
- W2091455840 hasVolume "22" @default.
- W2091455840 isParatext "false" @default.
- W2091455840 isRetracted "false" @default.
- W2091455840 magId "2091455840" @default.
- W2091455840 workType "article" @default.