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- W2091465606 abstract "Abstract Liver glycogen content was determined after administration of Δ 9 -tetrahydrocannabinol (Δ 9 -THC) to monkeys I.V. for 28 days, to rabbits S.C. for 28 days, and to rats by a single inhalation exposure. Δ 9 -THC doses above 4 mg/kg depressed liver glycogen stores by 60–75% in monkeys with no change in blood glucose. In the rabbit, 15–153 mg/kg initiated a 45–72% dose-related decline in liver glycogen. Rats subjected to inhalation of 34–100 mg/kg responed with a dose-related 20–26% decrease in liver glycogen within 24 hrs. which intensified to a 33–74% fall 7 days post exposure. It is suggested that depleted liver glycogen stores arise from both a nonspecific stress and the necessity for oxidizable substrate for detoxification of cannabinoid." @default.
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- W2091465606 date "1973-05-01" @default.
- W2091465606 modified "2023-09-26" @default.
- W2091465606 title "Cannabinoid effects on liver glycogen stores" @default.
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- W2091465606 doi "https://doi.org/10.1016/0024-3205(73)90323-8" @default.
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