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• W2091467206 abstract "We investigated the correlation between the apolipoprotein E ɛ4 allele (apoE ɛ4) carrier status, a major risk factor of Alzheimer's disease (AD), and levels of tau protein phosphorylated at threonine 231 (P-tau231P) in cerebrospinal fluid (CSF) in predementia and clinical stages of AD and healthy controls (HC). Thirty-one subjects with mild cognitive impairment (MCI) who had converted to AD during follow-up were included, as well as 71 AD patients, and 29 HC subjects. In MCI, but not in AD and HC, CSF P-tau231P levels were significantly higher in apoE ɛ4 carriers compared to non-carriers (p < 0.001). Controlling for disease duration, the apoE ɛ4 effect on P-tau231P remained significant. Our study indicates that the apoE ɛ4 carrier status should be considered when CSF P-tau231P is evaluated as biomarker candidate of AD in MCI subjects." @default.
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• W2091467206 date "2005-12-01" @default.
• W2091467206 modified "2023-10-16" @default.
• W2091467206 title "Increased levels of CSF phosphorylated tau in apolipoprotein E ɛ4 carriers with mild cognitive impairment" @default.
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• W2091467206 doi "https://doi.org/10.1016/j.neulet.2005.08.030" @default.
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