Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091467497> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2091467497 endingPage "464???470" @default.
- W2091467497 startingPage "464???470" @default.
- W2091467497 abstract "This study investigated whether the convulsant gas flurothyl deviates from the correlation between anesthetic potency and lipid solubility. Flurothyl (CF3CH2OCH2CF3) produced convulsions in 50% of mice at 0.122 +/- 0.006% atm. Mice often convulsed repeatedly after exposure to flurothyl, the maximum number of convulsions occurring when the concentration was 0.24% atm. Concentrations greater than 0.6% atm produced convulsions immediately after addition of flurothyl, but rarely at later times. An ED50 value for loss of the righting reflex was obtained when the concentration was 1.22 +/- 0.19% atm. The oil/gas partition coefficient was found to be 46.9 for flurothyl at 37 C. The product of righting-reflex ED50 and oil/gas partition coefficient (0.0122 atm x 46.9 = 0.57 atm) is similar to that found for conventional anaesthetics in mice. Therefore, flurothyl does not deviate from the correlation of anesthetic potency and lipid solubility. It was also found that 0.3 to 0.8% atm flurothyl increased isoflurane MAC in dogs, but that 3 to 4% atm flurothyl decreased it. The increase of isoflurane requirement at lower concentrations of flurothyl suggests that anesthetics with a potential to cause convulsions may partly antagonize their own anesthetic effect. The decrease in isoflurane MAC in dogs at higher concentrations of flurothyl also implies that this compound has an anesthetic effect. A structural isomer of flurothyl, iso-Indoklon [(CSF3)2CHOCH3], was only anesthetic and did not have convulsant properties. Its MAC in dogs was 4.60 +/- 0.45% atm, and its righting-reflex ED50 in mice was 2.65 +/- 0.13% atm. The product of iso-Indoklon MAC in dogs and its oil/gas partition coefficient (27.0) was 1.24 atm, and the product of iso-Indoklon righting-reflex ED50 in mice and oil/gas partition coefficient was 0.72 atm. These values are close to those found for conventional anesthetic agents in dogs and mice; thus iso-Indoklon also does not deviate from the correlation between anesthetic potency and lipid solubilities." @default.
- W2091467497 created "2016-06-24" @default.
- W2091467497 creator A5017598593 @default.
- W2091467497 creator A5026287401 @default.
- W2091467497 creator A5045652685 @default.
- W2091467497 creator A5047166116 @default.
- W2091467497 creator A5070944092 @default.
- W2091467497 creator A5091303817 @default.
- W2091467497 date "1981-07-01" @default.
- W2091467497 modified "2023-10-16" @default.
- W2091467497 title "Are Convulsant Gases Also Anesthetics?" @default.
- W2091467497 doi "https://doi.org/10.1213/00000539-198107000-00002" @default.
- W2091467497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7195661" @default.
- W2091467497 hasPublicationYear "1981" @default.
- W2091467497 type Work @default.
- W2091467497 sameAs 2091467497 @default.
- W2091467497 citedByCount "20" @default.
- W2091467497 countsByYear W20914674972015 @default.
- W2091467497 countsByYear W20914674972017 @default.
- W2091467497 countsByYear W20914674972022 @default.
- W2091467497 crossrefType "journal-article" @default.
- W2091467497 hasAuthorship W2091467497A5017598593 @default.
- W2091467497 hasAuthorship W2091467497A5026287401 @default.
- W2091467497 hasAuthorship W2091467497A5045652685 @default.
- W2091467497 hasAuthorship W2091467497A5047166116 @default.
- W2091467497 hasAuthorship W2091467497A5070944092 @default.
- W2091467497 hasAuthorship W2091467497A5091303817 @default.
- W2091467497 hasBestOaLocation W20914674971 @default.
- W2091467497 hasConcept C126322002 @default.
- W2091467497 hasConcept C131783052 @default.
- W2091467497 hasConcept C170493617 @default.
- W2091467497 hasConcept C185592680 @default.
- W2091467497 hasConcept C202751555 @default.
- W2091467497 hasConcept C2776359302 @default.
- W2091467497 hasConcept C2776932660 @default.
- W2091467497 hasConcept C2778162923 @default.
- W2091467497 hasConcept C2778900099 @default.
- W2091467497 hasConcept C42219234 @default.
- W2091467497 hasConcept C42533223 @default.
- W2091467497 hasConcept C55493867 @default.
- W2091467497 hasConcept C57992300 @default.
- W2091467497 hasConcept C71924100 @default.
- W2091467497 hasConcept C83974742 @default.
- W2091467497 hasConcept C98274493 @default.
- W2091467497 hasConceptScore W2091467497C126322002 @default.
- W2091467497 hasConceptScore W2091467497C131783052 @default.
- W2091467497 hasConceptScore W2091467497C170493617 @default.
- W2091467497 hasConceptScore W2091467497C185592680 @default.
- W2091467497 hasConceptScore W2091467497C202751555 @default.
- W2091467497 hasConceptScore W2091467497C2776359302 @default.
- W2091467497 hasConceptScore W2091467497C2776932660 @default.
- W2091467497 hasConceptScore W2091467497C2778162923 @default.
- W2091467497 hasConceptScore W2091467497C2778900099 @default.
- W2091467497 hasConceptScore W2091467497C42219234 @default.
- W2091467497 hasConceptScore W2091467497C42533223 @default.
- W2091467497 hasConceptScore W2091467497C55493867 @default.
- W2091467497 hasConceptScore W2091467497C57992300 @default.
- W2091467497 hasConceptScore W2091467497C71924100 @default.
- W2091467497 hasConceptScore W2091467497C83974742 @default.
- W2091467497 hasConceptScore W2091467497C98274493 @default.
- W2091467497 hasIssue "7" @default.
- W2091467497 hasLocation W20914674971 @default.
- W2091467497 hasLocation W20914674972 @default.
- W2091467497 hasLocation W20914674973 @default.
- W2091467497 hasOpenAccess W2091467497 @default.
- W2091467497 hasPrimaryLocation W20914674971 @default.
- W2091467497 hasRelatedWork W1949399753 @default.
- W2091467497 hasRelatedWork W1965452294 @default.
- W2091467497 hasRelatedWork W2012680029 @default.
- W2091467497 hasRelatedWork W2064331062 @default.
- W2091467497 hasRelatedWork W2064411302 @default.
- W2091467497 hasRelatedWork W2071844296 @default.
- W2091467497 hasRelatedWork W2091467497 @default.
- W2091467497 hasRelatedWork W2127068541 @default.
- W2091467497 hasRelatedWork W2414260968 @default.
- W2091467497 hasRelatedWork W4238058519 @default.
- W2091467497 hasVolume "60" @default.
- W2091467497 isParatext "false" @default.
- W2091467497 isRetracted "false" @default.
- W2091467497 magId "2091467497" @default.
- W2091467497 workType "article" @default.