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• W2091479079 abstract "Electrophysiological and computational evidence indicate that the excitatory current from the synapses on the somato-dendritic membrane is not large enough to drive the motoneurones to the firing frequencies actually attained under normal motor activity. It has been proposed that this paradox could be explained if the voltage-dependent persistent inward currents (PICs) present in the dendrites of motoneurones served to amplify synaptic excitation. We report here that dendritic PICs cause a large amplification of synaptic excitation, and that this amplification is enhanced when the background firing by current injection is increased. Moreover the frequency reduction by synaptic inhibition is greatly enhanced at higher firing frequencies, when the current through the recording electrode has activated the dendritic PICs, as is the case when the current-to-frequency slope suddenly becomes steeper. We also demonstrate that synaptic inhibition is several times more effective in reducing the firing caused by synaptic excitation than firing evoked by current injection through the recording microelectrode. That would be explained if motoneuronal discharge by synaptic excitation--but not by current injection in the soma--is always supported by dendritic PICs. We conclude that dendritic PICs contribute dynamically to the transformation of synaptic input into a motoneuronal frequency code." @default.
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• W2091479079 date "2003-11-01" @default.
• W2091479079 modified "2023-10-15" @default.
• W2091479079 title "Variable amplification of synaptic input to cat spinal motoneurones by dendritic persistent inward current" @default.
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• W2091479079 doi "https://doi.org/10.1113/jphysiol.2003.050971" @default.
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