FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091487504> ?p ?o ?g. }

• W2091487504 endingPage "138" @default.
• W2091487504 startingPage "128" @default.
• W2091487504 abstract "Abstract Chronic graft rejection mediated by cellular immune responses still poses a serious clinical problem in transplant surgery. Chemokines coordinate the recruitment of leukocytes in inflammatory and immune responses. Their precise functions in the rejection of allografts are still ill defined. This study investigates the role of chemokine receptor 4 (CCR4) in acute and chronic cardiac allograft rejection in mice. Allogeneic hearts were transplanted into CCR4 deficient (CCR4 –/– ) and control recipients. Reverse transcription‐PCR showed transcription of macrophage‐derived chemokine and thymus and activation‐regulated chemokine, the cognate chemokine ligands of CCR4, within the graft. Compared to wild‐type controls, acute allograft rejection in CCR4 –/– recipients was only slightly prolonged. In contrast, in a gallium nitrate chronic cardiac allograft rejection model, cardiac graft survival was significantly prolonged in CCR4 –/– recipients. A relative increase in the percentage of graft infiltrating CD8 + T cells in CCR4 –/– recipients was observed 30 days after transplantation and was accompanied by a decrease in CD4 + T cells. Moreover, the percentage of NK1.1 + CD3 + graft‐infiltrating cells was significantly reduced on day 5 and day 30 post transplantation. These findings indicate that CCR4 is involved in the recruitment of NK1.1 + CD3 + cells into cardiac allografts and clearly establish an important and novel role for CCR4 in chronic graft rejection." @default.
• W2091487504 created "2016-06-24" @default.
• W2091487504 creator A5001163334 @default.
• W2091487504 creator A5018309185 @default.
• W2091487504 creator A5029115834 @default.
• W2091487504 creator A5032489562 @default.
• W2091487504 creator A5033366410 @default.
• W2091487504 creator A5039842502 @default.
• W2091487504 creator A5061123633 @default.
• W2091487504 creator A5071176587 @default.
• W2091487504 creator A5088522084 @default.
• W2091487504 date "2004-12-16" @default.
• W2091487504 modified "2023-10-11" @default.
• W2091487504 title "CCR4-deficient mice show prolonged graft survival in a chronic cardiac transplant rejection model" @default.
• W2091487504 cites W1511263879 @default.
• W2091487504 cites W1593435314 @default.
• W2091487504 cites W1965058145 @default.
• W2091487504 cites W1970548110 @default.
• W2091487504 cites W1977694310 @default.
• W2091487504 cites W1985277568 @default.
• W2091487504 cites W1986991315 @default.
• W2091487504 cites W2001146686 @default.
• W2091487504 cites W2014125703 @default.
• W2091487504 cites W2020617877 @default.
• W2091487504 cites W2022493256 @default.
• W2091487504 cites W2025575764 @default.
• W2091487504 cites W2026240949 @default.
• W2091487504 cites W2032494769 @default.
• W2091487504 cites W2036039626 @default.
• W2091487504 cites W2037572297 @default.
• W2091487504 cites W2038610464 @default.
• W2091487504 cites W2038632268 @default.
• W2091487504 cites W2042212610 @default.
• W2091487504 cites W2042412331 @default.
• W2091487504 cites W2042626190 @default.
• W2091487504 cites W2044996210 @default.
• W2091487504 cites W2059797460 @default.
• W2091487504 cites W2065709904 @default.
• W2091487504 cites W2067846827 @default.
• W2091487504 cites W2077427214 @default.
• W2091487504 cites W2086570008 @default.
• W2091487504 cites W2091835729 @default.
• W2091487504 cites W2099675490 @default.
• W2091487504 cites W2103384599 @default.
• W2091487504 cites W2104328722 @default.
• W2091487504 cites W2112495824 @default.
• W2091487504 cites W2113238601 @default.
• W2091487504 cites W2114137481 @default.
• W2091487504 cites W2114531423 @default.
• W2091487504 cites W2114962227 @default.
• W2091487504 cites W2115289037 @default.
• W2091487504 cites W2116493322 @default.
• W2091487504 cites W2117342688 @default.
• W2091487504 cites W2118526748 @default.
• W2091487504 cites W2131170047 @default.
• W2091487504 cites W2134486617 @default.
• W2091487504 cites W2149116434 @default.
• W2091487504 cites W2154685907 @default.
• W2091487504 cites W2160129587 @default.
• W2091487504 cites W2161234218 @default.
• W2091487504 cites W2161307276 @default.
• W2091487504 cites W2170737790 @default.
• W2091487504 cites W2189453901 @default.
• W2091487504 cites W4250399467 @default.
• W2091487504 cites W4313331406 @default.
• W2091487504 doi "https://doi.org/10.1002/eji.200324745" @default.
• W2091487504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15593118" @default.
• W2091487504 hasPublicationYear "2004" @default.
• W2091487504 type Work @default.
• W2091487504 sameAs 2091487504 @default.
• W2091487504 citedByCount "30" @default.
• W2091487504 countsByYear W20914875042012 @default.
• W2091487504 countsByYear W20914875042013 @default.
• W2091487504 countsByYear W20914875042014 @default.
• W2091487504 countsByYear W20914875042015 @default.
• W2091487504 countsByYear W20914875042016 @default.
• W2091487504 countsByYear W20914875042017 @default.
• W2091487504 countsByYear W20914875042018 @default.
• W2091487504 countsByYear W20914875042019 @default.
• W2091487504 countsByYear W20914875042021 @default.
• W2091487504 countsByYear W20914875042022 @default.
• W2091487504 crossrefType "journal-article" @default.
• W2091487504 hasAuthorship W2091487504A5001163334 @default.
• W2091487504 hasAuthorship W2091487504A5018309185 @default.
• W2091487504 hasAuthorship W2091487504A5029115834 @default.
• W2091487504 hasAuthorship W2091487504A5032489562 @default.
• W2091487504 hasAuthorship W2091487504A5033366410 @default.
• W2091487504 hasAuthorship W2091487504A5039842502 @default.
• W2091487504 hasAuthorship W2091487504A5061123633 @default.
• W2091487504 hasAuthorship W2091487504A5071176587 @default.
• W2091487504 hasAuthorship W2091487504A5088522084 @default.
• W2091487504 hasBestOaLocation W20914875041 @default.
• W2091487504 hasConcept C114684123 @default.
• W2091487504 hasConcept C126322002 @default.
• W2091487504 hasConcept C12823836 @default.
• W2091487504 hasConcept C13373296 @default.
• W2091487504 hasConcept C154317977 @default.
• W2091487504 hasConcept C167672396 @default.

• next