FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091489434> ?p ?o ?g. }

• W2091489434 endingPage "35769" @default.
• W2091489434 startingPage "35759" @default.
• W2091489434 abstract "MyD88 is an essential adaptor molecule for Toll-like receptors (TLRs) and interleukin (IL)-1 receptor. MyD88 is thought to be present as condensed forms or aggregated structures in the cytoplasm, although the reason has not yet been clear. Here, we show that endogenous MyD88 is present as small speckle-like condensed structures, formation of which depends on MyD88 dimerization. In addition, formation of large aggregated structures is related to cytoplasmic accumulation of sequestosome 1 (SQSTM1; also known as p62) and histone deacetylase 6 (HDAC6), which are involved in accumulation of polyubiquitinated proteins. A gene knockdown study revealed that SQSTM1 and HDAC6 were required for MyD88 aggregation and exhibited a suppressive effect on TLR ligand-induced expression of IL-6 and NOS2 in RAW264.7 cells. SQSTM1 and HDAC6 were partially involved in suppression of several TLR4-mediated signaling events, including activation of p38 and JNK, but they hardly affected degradation of IκBα (inhibitor of nuclear factor κB). Biochemical induction of MyD88 oligomerization induced recruitment of SQSTM1 and HDAC6 to the MyD88-TRAF6 signaling complex. Repression of SQSTM1 and HDAC6 enhanced formation of the MyD88-TRAF6 complex and conversely decreased interaction of the ubiquitin-specific negative regulator CYLD with the complex. Furthermore, ubiquitin-binding regions on SQSTM1 and HDAC6 were essential for MyD88 aggregation but were not required for interaction with the MyD88 complex. Thus, our study reveals not only that SQSTM1 and HDAC6 are important determinants of aggregated localization of MyD88 but also that MyD88 activates a machinery of polyubiquitinated protein accumulation that has a modulatory effect on MyD88-dependent signal transduction." @default.
• W2091489434 created "2016-06-24" @default.
• W2091489434 creator A5014119193 @default.
• W2091489434 creator A5019726395 @default.
• W2091489434 creator A5038725297 @default.
• W2091489434 creator A5081483210 @default.
• W2091489434 creator A5082018968 @default.
• W2091489434 date "2010-11-01" @default.
• W2091489434 modified "2023-09-26" @default.
• W2091489434 title "Regulation of MyD88 Aggregation and the MyD88-dependent Signaling Pathway by Sequestosome 1 and Histone Deacetylase 6" @default.
• W2091489434 cites W1539659593 @default.
• W2091489434 cites W1580121471 @default.
• W2091489434 cites W1588312796 @default.
• W2091489434 cites W1964033480 @default.
• W2091489434 cites W1965971815 @default.
• W2091489434 cites W1968440197 @default.
• W2091489434 cites W1969430178 @default.
• W2091489434 cites W1969501356 @default.
• W2091489434 cites W1992133603 @default.
• W2091489434 cites W1993211211 @default.
• W2091489434 cites W1995744610 @default.
• W2091489434 cites W1995747121 @default.
• W2091489434 cites W1997112179 @default.
• W2091489434 cites W2002288000 @default.
• W2091489434 cites W2005739512 @default.
• W2091489434 cites W2013586539 @default.
• W2091489434 cites W2017883909 @default.
• W2091489434 cites W2018636808 @default.
• W2091489434 cites W2026938943 @default.
• W2091489434 cites W2037454778 @default.
• W2091489434 cites W2043801813 @default.
• W2091489434 cites W2043823247 @default.
• W2091489434 cites W2056092077 @default.
• W2091489434 cites W2057518766 @default.
• W2091489434 cites W2065866791 @default.
• W2091489434 cites W2077995361 @default.
• W2091489434 cites W2080920431 @default.
• W2091489434 cites W2090926709 @default.
• W2091489434 cites W2095668509 @default.
• W2091489434 cites W2097360510 @default.
• W2091489434 cites W2098257571 @default.
• W2091489434 cites W2111922856 @default.
• W2091489434 cites W2115185894 @default.
• W2091489434 cites W2115620208 @default.
• W2091489434 cites W2119399459 @default.
• W2091489434 cites W2119579802 @default.
• W2091489434 cites W2134192973 @default.
• W2091489434 cites W2135140747 @default.
• W2091489434 cites W2145266709 @default.
• W2091489434 cites W2146124002 @default.
• W2091489434 cites W2146204355 @default.
• W2091489434 cites W2168393359 @default.
• W2091489434 cites W2169904105 @default.
• W2091489434 doi "https://doi.org/10.1074/jbc.m110.126904" @default.
• W2091489434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2975200" @default.
• W2091489434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20837465" @default.
• W2091489434 hasPublicationYear "2010" @default.
• W2091489434 type Work @default.
• W2091489434 sameAs 2091489434 @default.
• W2091489434 citedByCount "75" @default.
• W2091489434 countsByYear W20914894342012 @default.
• W2091489434 countsByYear W20914894342013 @default.
• W2091489434 countsByYear W20914894342014 @default.
• W2091489434 countsByYear W20914894342015 @default.
• W2091489434 countsByYear W20914894342016 @default.
• W2091489434 countsByYear W20914894342017 @default.
• W2091489434 countsByYear W20914894342018 @default.
• W2091489434 countsByYear W20914894342019 @default.
• W2091489434 countsByYear W20914894342020 @default.
• W2091489434 countsByYear W20914894342021 @default.
• W2091489434 countsByYear W20914894342022 @default.
• W2091489434 countsByYear W20914894342023 @default.
• W2091489434 crossrefType "journal-article" @default.
• W2091489434 hasAuthorship W2091489434A5014119193 @default.
• W2091489434 hasAuthorship W2091489434A5019726395 @default.
• W2091489434 hasAuthorship W2091489434A5038725297 @default.
• W2091489434 hasAuthorship W2091489434A5081483210 @default.
• W2091489434 hasAuthorship W2091489434A5082018968 @default.
• W2091489434 hasBestOaLocation W20914894341 @default.
• W2091489434 hasConcept C104317684 @default.
• W2091489434 hasConcept C170493617 @default.
• W2091489434 hasConcept C183786373 @default.
• W2091489434 hasConcept C185592680 @default.
• W2091489434 hasConcept C190283241 @default.
• W2091489434 hasConcept C203522944 @default.
• W2091489434 hasConcept C23681527 @default.
• W2091489434 hasConcept C25602115 @default.
• W2091489434 hasConcept C2778305200 @default.
• W2091489434 hasConcept C2908656506 @default.
• W2091489434 hasConcept C55493867 @default.
• W2091489434 hasConcept C62478195 @default.
• W2091489434 hasConcept C64927066 @default.
• W2091489434 hasConcept C86803240 @default.
• W2091489434 hasConcept C95444343 @default.
• W2091489434 hasConceptScore W2091489434C104317684 @default.
• W2091489434 hasConceptScore W2091489434C170493617 @default.
• W2091489434 hasConceptScore W2091489434C183786373 @default.
• W2091489434 hasConceptScore W2091489434C185592680 @default.

• next