FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091494858> ?p ?o ?g. }

• W2091494858 endingPage "96" @default.
• W2091494858 startingPage "91" @default.
• W2091494858 abstract "Stroke therapy may be optimized by combination therapy with both a neuroprotective neurotrophin and an anti-inflammatory agent. In the present work, the model neurotrophin is glial cell line-derived neurotrophic factor (GDNF), and the model anti-inflammatory agent is the type II tumor necrosis factor receptor (TNFR) decoy receptor. Both the GDNF and the TNFR are large molecules that do not cross the blood–brain barrier (BBB), which is intact in the early hours after stroke when neural rescue is still possible. The GDNF and the TNFR decoy receptor were re-engineered for BBB transport as IgG fusion proteins, wherein the GDNF or the TNFR are fused to the heavy chain of a chimeric monoclonal antibody (MAb) against the mouse transferrin receptor (TfR), and these fusion proteins are designated cTfRMAb–GDNF and cTfRMAb–TNFR, respectively. Mice were treated intravenously with (a) saline, (b) GDNF alone, (c) the cTfRMAb–GDNF fusion protein alone, or (d) the combined cTfRMAb–GDNF and cTfRMAb–TNFR fusion proteins, following a 1-h reversible middle cerebral artery occlusion (MCAO). The cTfRMAb–GDNF fusion protein alone caused a significant 25% and 30% reduction in hemispheric and cortical stroke volumes. Combined treatment with the cTfRMAb–GDNF and cTfRMAb–TNFR fusion proteins caused a significant 54%, 69% and 30% reduction in hemispheric, cortical and subcortical stroke volumes. Conversely, intravenous GDNF had no therapeutic effect. In conclusion, combination treatment with BBB penetrating IgG–GDNF and IgG–TNFR fusion proteins enhances the therapeutic effect of single treatment with the IgG–GDNF fusion protein following delayed intravenous administration in acute stroke." @default.
• W2091494858 created "2016-06-24" @default.
• W2091494858 creator A5027480548 @default.
• W2091494858 creator A5066252030 @default.
• W2091494858 creator A5073892880 @default.
• W2091494858 date "2013-04-01" @default.
• W2091494858 modified "2023-09-27" @default.
• W2091494858 title "Combination stroke therapy in the mouse with blood–brain barrier penetrating IgG–GDNF and IgG–TNF decoy receptor fusion proteins" @default.
• W2091494858 cites W1968547636 @default.
• W2091494858 cites W1996719014 @default.
• W2091494858 cites W2002604140 @default.
• W2091494858 cites W2017836293 @default.
• W2091494858 cites W2018971408 @default.
• W2091494858 cites W2025702750 @default.
• W2091494858 cites W2027276248 @default.
• W2091494858 cites W2034882426 @default.
• W2091494858 cites W2034941414 @default.
• W2091494858 cites W2039861484 @default.
• W2091494858 cites W2040957577 @default.
• W2091494858 cites W2044450404 @default.
• W2091494858 cites W2047212809 @default.
• W2091494858 cites W2058733470 @default.
• W2091494858 cites W2060066888 @default.
• W2091494858 cites W2060560910 @default.
• W2091494858 cites W2067436359 @default.
• W2091494858 cites W2072567425 @default.
• W2091494858 cites W2077099362 @default.
• W2091494858 cites W2083284350 @default.
• W2091494858 cites W2090014647 @default.
• W2091494858 cites W2102754060 @default.
• W2091494858 cites W2106606256 @default.
• W2091494858 cites W2110521417 @default.
• W2091494858 cites W2116765510 @default.
• W2091494858 cites W2132895844 @default.
• W2091494858 cites W2135418827 @default.
• W2091494858 cites W2138903446 @default.
• W2091494858 cites W2145371242 @default.
• W2091494858 cites W2147806414 @default.
• W2091494858 cites W2148714038 @default.
• W2091494858 cites W2157521028 @default.
• W2091494858 cites W2163094232 @default.
• W2091494858 cites W2167706707 @default.
• W2091494858 cites W2170525987 @default.
• W2091494858 cites W2417346988 @default.
• W2091494858 doi "https://doi.org/10.1016/j.brainres.2013.02.022" @default.
• W2091494858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23428543" @default.
• W2091494858 hasPublicationYear "2013" @default.
• W2091494858 type Work @default.
• W2091494858 sameAs 2091494858 @default.
• W2091494858 citedByCount "27" @default.
• W2091494858 countsByYear W20914948582014 @default.
• W2091494858 countsByYear W20914948582015 @default.
• W2091494858 countsByYear W20914948582016 @default.
• W2091494858 countsByYear W20914948582017 @default.
• W2091494858 countsByYear W20914948582018 @default.
• W2091494858 countsByYear W20914948582019 @default.
• W2091494858 countsByYear W20914948582020 @default.
• W2091494858 countsByYear W20914948582021 @default.
• W2091494858 countsByYear W20914948582022 @default.
• W2091494858 countsByYear W20914948582023 @default.
• W2091494858 crossrefType "journal-article" @default.
• W2091494858 hasAuthorship W2091494858A5027480548 @default.
• W2091494858 hasAuthorship W2091494858A5066252030 @default.
• W2091494858 hasAuthorship W2091494858A5073892880 @default.
• W2091494858 hasConcept C104317684 @default.
• W2091494858 hasConcept C123894998 @default.
• W2091494858 hasConcept C126322002 @default.
• W2091494858 hasConcept C160539049 @default.
• W2091494858 hasConcept C170493617 @default.
• W2091494858 hasConcept C185592680 @default.
• W2091494858 hasConcept C185856081 @default.
• W2091494858 hasConcept C203014093 @default.
• W2091494858 hasConcept C25498285 @default.
• W2091494858 hasConcept C2779179475 @default.
• W2091494858 hasConcept C40767141 @default.
• W2091494858 hasConcept C55493867 @default.
• W2091494858 hasConcept C71924100 @default.
• W2091494858 hasConcept C98274493 @default.
• W2091494858 hasConceptScore W2091494858C104317684 @default.
• W2091494858 hasConceptScore W2091494858C123894998 @default.
• W2091494858 hasConceptScore W2091494858C126322002 @default.
• W2091494858 hasConceptScore W2091494858C160539049 @default.
• W2091494858 hasConceptScore W2091494858C170493617 @default.
• W2091494858 hasConceptScore W2091494858C185592680 @default.
• W2091494858 hasConceptScore W2091494858C185856081 @default.
• W2091494858 hasConceptScore W2091494858C203014093 @default.
• W2091494858 hasConceptScore W2091494858C25498285 @default.
• W2091494858 hasConceptScore W2091494858C2779179475 @default.
• W2091494858 hasConceptScore W2091494858C40767141 @default.
• W2091494858 hasConceptScore W2091494858C55493867 @default.
• W2091494858 hasConceptScore W2091494858C71924100 @default.
• W2091494858 hasConceptScore W2091494858C98274493 @default.
• W2091494858 hasLocation W20914948581 @default.
• W2091494858 hasLocation W20914948582 @default.
• W2091494858 hasOpenAccess W2091494858 @default.
• W2091494858 hasPrimaryLocation W20914948581 @default.
• W2091494858 hasRelatedWork W2028690144 @default.
• W2091494858 hasRelatedWork W2072567425 @default.

• next