FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091495904> ?p ?o ?g. }

• W2091495904 endingPage "372" @default.
• W2091495904 startingPage "363" @default.
• W2091495904 abstract "Human and nonhuman primates have multiple DR B1 and non-B1 alleles. However, the role of mismatched DR non-B1 alleles in primary alloimmune responses is not well understood. Macaques, which share close DNA homologies with human MHC genes and have a high number of beta-chain genes in the DR subregion, are preeminent preclinical models for immunologic studies of transplant tolerance and immunosuppression. In this study, we examined the effect of allogeneic MHC Class II DRB mismatches in Th1- and Th2-like cytokine responses elicited in one-way MLR cultures in rhesus macaques. An ELISPOT method was used to estimate cytokine secretion at the single cell level. Molecular typing for DRB1 and DR non-B1 alleles was performed by a moderate-high resolution PCR-SSP method using a panel of 55 primer pairs covering 74 DRB alleles and clusters. Of 35 unrelated combinations, 66% had multiple (> or = 2) allelic MM at DRB1 and DR non-B1 with no significant correlation between numbers of DRB1 and DR non-B1 mismatches. Pairs with 1 or 0 MM were assigned to a mono/null MM group to obtain sufficient numbers for statistical analysis. The pairs differing by multiple vs. mono/null DRB1 MM showed no significant difference in cytokine prevalence (P = 0.69). In contrast, high IFN-gamma/ IL4 SFC ratios were noted in pairs with multiple vs. mono/null DR non-B1 MM (p = 0.0009). IFN-gamma/IL-10 spot forming cell (SFC) ratios were consistent with IFN-gamma/IL-4 SFC ratios (r = 0.98). Multiple DR non-B1 mismatches showed a trend towards higher MLR proliferative responses, although the stimulation index did not reflect the dominant cytokine response. These observations suggest a bias towards Th1-like cytokine production under allostimulation with multiple DR non-B1 gene products. Further study of the primary structure of DR non-B1 determinants may be helpful in understanding the fine molecular mechanisms governing the regulation of cytokine profiles during allostimulation in primates." @default.
• W2091495904 created "2016-06-24" @default.
• W2091495904 creator A5000289498 @default.
• W2091495904 creator A5008962949 @default.
• W2091495904 creator A5014029899 @default.
• W2091495904 creator A5039198226 @default.
• W2091495904 creator A5046033039 @default.
• W2091495904 creator A5086257394 @default.
• W2091495904 date "1998-06-01" @default.
• W2091495904 modified "2023-10-18" @default.
• W2091495904 title "DR Non-B1 Mismatches Influence Allogeneic MLR-Induced TH1- or TH2-Like Cytokine Responses in Rhesus Monkeys" @default.
• W2091495904 cites W1465758259 @default.
• W2091495904 cites W1515251449 @default.
• W2091495904 cites W1546384695 @default.
• W2091495904 cites W1552227471 @default.
• W2091495904 cites W1566811483 @default.
• W2091495904 cites W1871479351 @default.
• W2091495904 cites W1928333738 @default.
• W2091495904 cites W1942668068 @default.
• W2091495904 cites W1972807480 @default.
• W2091495904 cites W1975576603 @default.
• W2091495904 cites W1977945339 @default.
• W2091495904 cites W1979101101 @default.
• W2091495904 cites W1979720970 @default.
• W2091495904 cites W1980220231 @default.
• W2091495904 cites W1982505026 @default.
• W2091495904 cites W1983206935 @default.
• W2091495904 cites W1986725618 @default.
• W2091495904 cites W1998243760 @default.
• W2091495904 cites W1999203193 @default.
• W2091495904 cites W2001899369 @default.
• W2091495904 cites W2010505378 @default.
• W2091495904 cites W2019890895 @default.
• W2091495904 cites W2020977425 @default.
• W2091495904 cites W2021215107 @default.
• W2091495904 cites W2022181875 @default.
• W2091495904 cites W2025009691 @default.
• W2091495904 cites W2035876896 @default.
• W2091495904 cites W2058091324 @default.
• W2091495904 cites W2067200416 @default.
• W2091495904 cites W2077104972 @default.
• W2091495904 cites W2078198072 @default.
• W2091495904 cites W2078895073 @default.
• W2091495904 cites W2082775247 @default.
• W2091495904 cites W2083203972 @default.
• W2091495904 cites W2086449142 @default.
• W2091495904 cites W2090793595 @default.
• W2091495904 cites W2106416311 @default.
• W2091495904 cites W2108473659 @default.
• W2091495904 cites W2116803825 @default.
• W2091495904 cites W2140944306 @default.
• W2091495904 cites W2155229523 @default.
• W2091495904 cites W2158500407 @default.
• W2091495904 cites W2163354177 @default.
• W2091495904 cites W2172466148 @default.
• W2091495904 cites W2276404807 @default.
• W2091495904 cites W2442174845 @default.
• W2091495904 cites W4248923320 @default.
• W2091495904 doi "https://doi.org/10.1016/s0198-8859(98)00024-x" @default.
• W2091495904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9634198" @default.
• W2091495904 hasPublicationYear "1998" @default.
• W2091495904 type Work @default.
• W2091495904 sameAs 2091495904 @default.
• W2091495904 citedByCount "9" @default.
• W2091495904 crossrefType "journal-article" @default.
• W2091495904 hasAuthorship W2091495904A5000289498 @default.
• W2091495904 hasAuthorship W2091495904A5008962949 @default.
• W2091495904 hasAuthorship W2091495904A5014029899 @default.
• W2091495904 hasAuthorship W2091495904A5039198226 @default.
• W2091495904 hasAuthorship W2091495904A5046033039 @default.
• W2091495904 hasAuthorship W2091495904A5086257394 @default.
• W2091495904 hasConcept C104317684 @default.
• W2091495904 hasConcept C147483822 @default.
• W2091495904 hasConcept C153911025 @default.
• W2091495904 hasConcept C180754005 @default.
• W2091495904 hasConcept C191732599 @default.
• W2091495904 hasConcept C203014093 @default.
• W2091495904 hasConcept C207936829 @default.
• W2091495904 hasConcept C2776090121 @default.
• W2091495904 hasConcept C2778690821 @default.
• W2091495904 hasConcept C2779053233 @default.
• W2091495904 hasConcept C54355233 @default.
• W2091495904 hasConcept C57708383 @default.
• W2091495904 hasConcept C86803240 @default.
• W2091495904 hasConcept C8891405 @default.
• W2091495904 hasConceptScore W2091495904C104317684 @default.
• W2091495904 hasConceptScore W2091495904C147483822 @default.
• W2091495904 hasConceptScore W2091495904C153911025 @default.
• W2091495904 hasConceptScore W2091495904C180754005 @default.
• W2091495904 hasConceptScore W2091495904C191732599 @default.
• W2091495904 hasConceptScore W2091495904C203014093 @default.
• W2091495904 hasConceptScore W2091495904C207936829 @default.
• W2091495904 hasConceptScore W2091495904C2776090121 @default.
• W2091495904 hasConceptScore W2091495904C2778690821 @default.
• W2091495904 hasConceptScore W2091495904C2779053233 @default.
• W2091495904 hasConceptScore W2091495904C54355233 @default.
• W2091495904 hasConceptScore W2091495904C57708383 @default.
• W2091495904 hasConceptScore W2091495904C86803240 @default.

• next