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- W2091505967 abstract "1. Transplacental transfer of the anti-epileptic agent phenytoin (PHT), its phase I metabolite, p-hydroxy-phenytoin (p-OH-PHT), and its phase II conjugate p-OH-PHT-glucuronide, was studied in term placental lobules perfused single pass in both maternal and fetal circuits. 2. Ratios of clearance of PHT, p-OH-PHT and p-OH-PHT-glucuronide to clearance of antipyrine were 1.08 ± 0.03, 0.52 ± 0.02 and 0.12 ± 0.01 (mean and s.e.m.), respectively. 3. Transfer was positively correlated with lipophilicity as measured by the apparent partition coefficient determined between octanol and pH 7.4 buffer." @default.
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- W2091505967 date "1989-10-01" @default.
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- W2091505967 title "MATERNOFETAL TRANSFER OF PHENYTOIN, p-HYDROXY-PHENYTOIN AND p-HYDROXY-PHENYTOIN-GLUCURONIDE IN THE PERFUSED HUMAN PLACENTA" @default.
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- W2091505967 doi "https://doi.org/10.1111/j.1440-1681.1989.tb01517.x" @default.
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