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• W2091524995 startingPage "24305" @default.
• W2091524995 abstract "This study aimed to research the preparation and content determination of capsaicin-chitosan microspheres (CCMS) enteric coated tablets. The core tablets were prepared with the method of wet granulation. Nine formulae were designed to determine the optimal formula of the core tablet. Eudragit L100 was used to prepare the CCMS enteric-coated tablets. The effect of enteric coated formulation variables such as content of talc (10%, 25% and 40%), plasticisers (TEC and DBS), dosage of plasticiser (10%, 20% and 30%) and coating weight (2%, 3% and 5%) were evaluated for drug release characteristics. The in vitro release was studied using 0.1 N HCl and pH 6.8 phosphate buffer. Enteric coated tablets without ruptures or swelling behaviour over 2 h in 0.1 N HCl indicated that these tablets showed acid resistance. The accumulated release rate in phosphate buffer (pH 6.8) revealed that the prepared tablets were able to sustain drug release into the intestine and a first-order release was obtained for capsaicin. This research is the first report of the preparation and content determination of CCMS enteric coated tablets. The sustained release behavior of enteric coated formulations in pH 6.8 phosphate buffer demonstrated that it would be a potential drug delivery platform for sustained delivery of gastric irritant drugs." @default.
• W2091524995 created "2016-06-24" @default.
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• W2091524995 date "2013-12-13" @default.
• W2091524995 modified "2023-10-18" @default.
• W2091524995 title "The Preparation of Capsaicin-Chitosan Microspheres (CCMS) Enteric Coated Tablets" @default.
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• W2091524995 doi "https://doi.org/10.3390/ijms141224305" @default.
• W2091524995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3876112" @default.
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