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- W2091545048 abstract "The effect of hypoxia on high energy phosphate content in the myocardium of the newborn and adult rabbit was determined and compared with mechanical function. All studies were done using the arterially perfused septa, and hypoxia was induced using perfusate equilibrated with 95% N2 and 5% CO2. Adenosine triphosphate (ATP) and Creatine Phosphate (CP) were enzymatically determined by a fluorometric method. In the newborn, myocardial ATP content decreased after 2 minutes (min) of hypoxia but returned to control level between 10 and 30 min of hypoxia, and then decreased to 50% of control at 60 min. In contrast ATP content in the adult rabbit decreased continuously during hypoxia reaching 53% of control at 30 min and 29% at 60 min. The change In CP in both groups was similar to ATP. In the adult, reoxygenation after 10 min of hypoxia resulted in complete recovery, but in partial recovery after 30 or 60 min of hypoxia. The changes in myocardlal ATP content was similar to changes in mechanical function in both groups. The addition of Iodoacetic acid to the hypoxic perfusate in the newborn rabbit resulted in a significant depression in mechanical function and ATP content. The data suggest that the myocardium in the newborn as compared to the adult might be dependent on glycolytic rather than aerobic metabolism." @default.
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- W2091545048 date "1977-04-01" @default.
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- W2091545048 title "THE EFFECT OF HYPOXIA ON MYOCARDIAL HIGH ENERGY PHOSPHATE CONTENT IN THE NEWBORN AND ADULT RABBIT" @default.
- W2091545048 doi "https://doi.org/10.1203/00006450-197704000-00160" @default.
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