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- W2091567498 abstract "<h3>To the Editor.—</h3> The recent reports of toxic shock syndrome (TSS) during influenza outbreaks<sup>1,2</sup>may not imply a unique association with the influenza virus, but are more probably due to secondary focal staphylococcal infections including sinusitis—a frequent complication of influenza. The patient reported by Sperber and Francis<sup>1</sup>had clear-cut pneumonia, as did two of the nine patients reported by MacDonald et al<sup>2</sup>; the remainder could have had occult sinus infection. In either situation, it would not be unusual to culture<i>Staphylococcus aureus</i>from respiratory secretions. Such focal infections appear to be linked both epidemiologically and microbiologically to the pathogenesis of TSS.<sup>3</sup>During the last two influenza outbreaks in Denver, we have noted a large number of patients with secondary sinusitis. Growth of a toxin producing<i>S aureus</i>in a sinus (or in a lung) may provide conditions for toxin production that may not ordinarily be present" @default.
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- W2091567498 date "1987-06-12" @default.
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- W2091567498 title "Toxic Shock Syndrome, Staphylococcus aureus, and Influenza" @default.
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- W2091567498 doi "https://doi.org/10.1001/jama.1987.03390220068019" @default.
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