Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091567758> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2091567758 endingPage "478" @default.
- W2091567758 startingPage "470" @default.
- W2091567758 abstract "We compared the prophylactic efficacy of lithium, carbamazepine, and the combination and identified possible clinical markers of response.Fifty-two outpatients who met DSM-III-R criteria for bipolar illness were randomly assigned in a double-blind design for an intended 1 year of treatment with lithium or carbamazepine, a crossover to the opposite drug in the second year, and then a third year on the combination. Patients received monthly detailed evaluations, and daily life chart ratings of the degree of functional incapacity associated with mania or depression were completed.For evaluable patients: 13 (31.0%) of 42 failed to complete a full year of lithium therapy owing to lack of efficacy, and 2 dropped out because of side effects; 13 (37.1%) of 35 withdrew from carbamazepine within the first year owing to lack of efficacy, and 10 dropped out because of side effects (9 of the 10 had a rash); 7 (24.1%) of 29 withdrew from the combination therapy owing to lack of efficacy. The percentage of the evaluable patients who had marked or moderate improvement on the Clinical Global Impressions scale was 33.3% on lithium. 31.4% on carbamazepine, and 55.2% on the combination treatment, which was not significantly different. By a variety of measures, lithium was more effective than carbamazepine in the prophylaxis of mania. Patients with a past history of rapid cycling did poorly on monotherapy (28.0% responded to lithium; 19.0% responded to carbamazepine), but significantly better on the combination (56.3%, p < .05).These prospective, randomized data suggest a high incidence of inadequate response to either mood stabilizer or their combination despite use of adjunctive agents as needed. Additional novel treatment regimens are needed to better decrease affective morbidity in large numbers of bipolar outpatients." @default.
- W2091567758 created "2016-06-24" @default.
- W2091567758 creator A5003465612 @default.
- W2091567758 creator A5053329398 @default.
- W2091567758 creator A5054719819 @default.
- W2091567758 creator A5061068223 @default.
- W2091567758 creator A5081124023 @default.
- W2091567758 creator A5089075056 @default.
- W2091567758 date "1997-11-15" @default.
- W2091567758 modified "2023-10-17" @default.
- W2091567758 title "Comparative Prophylactic Efficacy of Lithium, Carbamazepine, and the Combination in Bipolar Disorder" @default.
- W2091567758 doi "https://doi.org/10.4088/jcp.v58n1102" @default.
- W2091567758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9413412" @default.
- W2091567758 hasPublicationYear "1997" @default.
- W2091567758 type Work @default.
- W2091567758 sameAs 2091567758 @default.
- W2091567758 citedByCount "286" @default.
- W2091567758 countsByYear W20915677582012 @default.
- W2091567758 countsByYear W20915677582013 @default.
- W2091567758 countsByYear W20915677582014 @default.
- W2091567758 countsByYear W20915677582015 @default.
- W2091567758 countsByYear W20915677582016 @default.
- W2091567758 countsByYear W20915677582017 @default.
- W2091567758 countsByYear W20915677582018 @default.
- W2091567758 countsByYear W20915677582019 @default.
- W2091567758 countsByYear W20915677582020 @default.
- W2091567758 countsByYear W20915677582021 @default.
- W2091567758 countsByYear W20915677582022 @default.
- W2091567758 countsByYear W20915677582023 @default.
- W2091567758 crossrefType "journal-article" @default.
- W2091567758 hasAuthorship W2091567758A5003465612 @default.
- W2091567758 hasAuthorship W2091567758A5053329398 @default.
- W2091567758 hasAuthorship W2091567758A5054719819 @default.
- W2091567758 hasAuthorship W2091567758A5061068223 @default.
- W2091567758 hasAuthorship W2091567758A5081124023 @default.
- W2091567758 hasAuthorship W2091567758A5089075056 @default.
- W2091567758 hasConcept C118552586 @default.
- W2091567758 hasConcept C126322002 @default.
- W2091567758 hasConcept C139719470 @default.
- W2091567758 hasConcept C142724271 @default.
- W2091567758 hasConcept C162324750 @default.
- W2091567758 hasConcept C204787440 @default.
- W2091567758 hasConcept C27081682 @default.
- W2091567758 hasConcept C2775858608 @default.
- W2091567758 hasConcept C2776174506 @default.
- W2091567758 hasConcept C2776809841 @default.
- W2091567758 hasConcept C2776867660 @default.
- W2091567758 hasConcept C2778186239 @default.
- W2091567758 hasConcept C2778541603 @default.
- W2091567758 hasConcept C2778570526 @default.
- W2091567758 hasConcept C2779253243 @default.
- W2091567758 hasConcept C71924100 @default.
- W2091567758 hasConcept C87813604 @default.
- W2091567758 hasConceptScore W2091567758C118552586 @default.
- W2091567758 hasConceptScore W2091567758C126322002 @default.
- W2091567758 hasConceptScore W2091567758C139719470 @default.
- W2091567758 hasConceptScore W2091567758C142724271 @default.
- W2091567758 hasConceptScore W2091567758C162324750 @default.
- W2091567758 hasConceptScore W2091567758C204787440 @default.
- W2091567758 hasConceptScore W2091567758C27081682 @default.
- W2091567758 hasConceptScore W2091567758C2775858608 @default.
- W2091567758 hasConceptScore W2091567758C2776174506 @default.
- W2091567758 hasConceptScore W2091567758C2776809841 @default.
- W2091567758 hasConceptScore W2091567758C2776867660 @default.
- W2091567758 hasConceptScore W2091567758C2778186239 @default.
- W2091567758 hasConceptScore W2091567758C2778541603 @default.
- W2091567758 hasConceptScore W2091567758C2778570526 @default.
- W2091567758 hasConceptScore W2091567758C2779253243 @default.
- W2091567758 hasConceptScore W2091567758C71924100 @default.
- W2091567758 hasConceptScore W2091567758C87813604 @default.
- W2091567758 hasIssue "11" @default.
- W2091567758 hasLocation W20915677581 @default.
- W2091567758 hasLocation W20915677582 @default.
- W2091567758 hasOpenAccess W2091567758 @default.
- W2091567758 hasPrimaryLocation W20915677581 @default.
- W2091567758 hasRelatedWork W1969760382 @default.
- W2091567758 hasRelatedWork W1970780326 @default.
- W2091567758 hasRelatedWork W1984304401 @default.
- W2091567758 hasRelatedWork W2066519361 @default.
- W2091567758 hasRelatedWork W2072053288 @default.
- W2091567758 hasRelatedWork W2153335219 @default.
- W2091567758 hasRelatedWork W2160980660 @default.
- W2091567758 hasRelatedWork W2429723649 @default.
- W2091567758 hasRelatedWork W2906906539 @default.
- W2091567758 hasRelatedWork W90052256 @default.
- W2091567758 hasVolume "58" @default.
- W2091567758 isParatext "false" @default.
- W2091567758 isRetracted "false" @default.
- W2091567758 magId "2091567758" @default.
- W2091567758 workType "article" @default.