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- W2091569159 abstract "THE ISOLATION OF AN ANDROGENIC STEROL, adrenosterone, from adrenal cortex extracts (I) provided a definite basis for relating the activities of the normal gland to the masculinising effects of certain cortical tumors. The present paper has as its object an evaluation of the degree to which the normal cortex functions as a source of physiologically active androgens by means of a study of the effect of adrenalectomy on the prostates of castrated rats.1 In analyzing the effects of adrenalectomy on the male reproductive system it has been considered of importance to maintain the general health of the animals as nearly normal as possible by the administration of desoxycorticosterone acetate.2 It has previously been shown that there occurs an anomalous maintenance of well differentiated epithelium in the prostate and seminal vesicles of rats and mice which were castrated at 3 weeks of age (2, 3, 4). In adults the maintenance of such conditions is dependent on the presence of androgens (5, 6)." @default.
- W2091569159 created "2016-06-24" @default.
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- W2091569159 date "1941-11-01" @default.
- W2091569159 modified "2023-09-27" @default.
- W2091569159 title "EFFECTS OF ADRENALECTOMY AND DESOXYCORTICOSTERONE SUBSTITUTION THERAPY ON THE CASTRATED RAT PROSTATE EVIDENCE FOR AN ANDROMIMETIC FUNCTION OF THE IMMATURE RAT ADRENAL" @default.
- W2091569159 doi "https://doi.org/10.1210/endo-29-5-746" @default.
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