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• W2091569328 abstract "Abstract 1. Intracellular recordings were made from identified central neurones from the snail, Helix aspersa . 2. Neurones were used which were inhibited by ionophoretic application of dopamine and a series of compounds examined for their potencies as dopamine antagonists. Potencies were determined in terms of pA 2 . 3. Ergometrine was the most potent antagonist with a pA 2 of 12.5 ± 0.1. Apomorphine and bromocriptine were less potent with pA 2 values of 8.4 ± 0.1 and 6.2 ± 0.2 respectively. 4. The benzamide sulpiride showed stereospecificity at this dopamine receptor since (−)-sulpiride and (+)-sulpiride possessed pA 2 values of 6.0 ± 0.1 and 4.7 ± 0.1 respectively. Zetidoline and the D1 selective antagonist SCH 23390 had pA 2 values of 5.3 ± 0.1 and 5.5 ± 0.1 respectively. 5. These results are discussed in terms of the D1 and D2 receptor classification for the Helix dopamine receptor." @default.
• W2091569328 created "2016-06-24" @default.
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• W2091569328 date "1988-01-01" @default.
• W2091569328 modified "2023-09-27" @default.
• W2091569328 title "Quantitative antagonist studies on dopamine inhibitory responses of Helix aspersa central neurones" @default.
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• W2091569328 doi "https://doi.org/10.1016/0742-8413(88)90197-1" @default.
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