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- W2091569584 abstract "Ultrastructural study of a hepatic metastasis from a malignant islet tumor—associated initially with duodenal ulceration and subsequently with severe diarrhea and hypokalemia—has revealed a dual cell population. The first cellular category comprised cells believed to be alpha cells. The nature of the second group is not clear; they may have represented modified alpha cells. In view of recent evidence incriminating gastrin as the factor responsible for gastric hypersecretion, and in view of the postulated existence of a separate hormone responsible for the severe diarrhea encountered in some patients with islet cell tumors, it is suggested that these two cellular variants may, respectively, have been responsible for the elaboration of factors mediating the physiologic disturbances present in this patient, viz., secretion of gastrin by the alpha cells, and of an intestinal stimulant by cells of the second category, whatever their derivation." @default.
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- W2091569584 date "1967-08-01" @default.
- W2091569584 modified "2023-09-23" @default.
- W2091569584 title "Some observations on the ultrastructure of a malignant islet cell tumor associated with duodenal ulceration and severe diarrhea" @default.
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- W2091569584 doi "https://doi.org/10.1016/s0022-5320(67)80078-9" @default.
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