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- W2091571812 abstract "In an article in this month's The Lancet Oncology, Bottomley and colleagues 1 Bottomly A Therasse P Piccart M et al. Health-related quality of life in survivors of locally advanced breast cancer: an international randomised controlled phase III trial. Lancet Oncol. 2005; 6: 287-294 Summary Full Text Full Text PDF PubMed Scopus (42) Google Scholar assessed health-related quality of life (HRQOL) in patients with locally advanced breast cancer who had been randomly assigned to standard dose (6 months) adjuvant chemotherapy of cyclophosphamide, epirubicin, and fluorouracil, or to a dose intensive (3 months) regimen of cyclophosphamide, epirubicin, and filgrastim in the context of a large international trial. As predicted, patients in the dose-intensive group showed greater decrements in HRQOL measured on the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 compared with those in the standard-dose group over the first 3 months. Importantly, however, no differences were seen between the groups at the 1-year assessment, and, for the most part, HRQOL scores were comparable to population norms after this assessment. These data confirm that dose-intensive regimens have a greater negative effect on HRQOL in the short term than do standard-dose regimens; however, these differences disappear over time. Health-related quality of life in survivors of locally advanced breast cancer: an international randomised controlled phase III trialDose-intensive treatment only has a temporary effect on HRQOL, thus enabling more research on intensive treatment for patients with locally advanced breast cancer. Published online April 7, 2005 DOI 10.1016/S1470-2045(05)70101-7 Full-Text PDF" @default.
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- W2091571812 date "2005-05-01" @default.
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- W2091571812 title "Effect of dose-intensive chemotherapy on quality of life" @default.
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- W2091571812 doi "https://doi.org/10.1016/s1470-2045(05)70143-1" @default.
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