FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091583893> ?p ?o ?g. }

• W2091583893 endingPage "1143" @default.
• W2091583893 startingPage "1131" @default.
• W2091583893 abstract "Although butylated hydroxytoluene (BHT) is non-mutagenic, at high doses it has recently been associated with an increased incidence of liver tumours in laboratory rodents. To establish whether chronic liver cell injury may be involved in the genesis of these tumours, BHT was administered to rats by orogastric gavage at doses of 0, 25, 250 or 500 mg/kg/day for up to 28 days and also at daily doses of 1000 and 1250 mg BHT/kg for up to 4 days (sublethal doses). The sublethal doses induced centrilobular necrosis within 48 hr, whereas administration of BHT for 7 or 28 days caused dose-related hepatomegaly and at the highest dose level induced progressive periportal hepatocyte necrosis. The periportal lesions were associated with proliferation of bile ducts, persistent fibrous and inflammatory cell reactions, hepatocyte hyperplasia and hepatocellular and nuclear hypertrophy. Biochemical changes consisted of dose-related induction of epoxide hydrolase, dose-related changes in the ratio of cytochrome P-450 isoenzymes and depression of glucose-6-phosphatase. Measurement of BHT demonstrated a dose-related accumulation in fat but not in the liver. Changes in hepatic activating and detoxifying enzyme profiles are implicated both in the mechanism of periportal hepatocyte damage and in the change of site of damage according to the dose and duration of the treatment. The persistent and active nature of the lesions in rats dosed with 500 mg BHT/kg for 28 days, combined with evidence of cell damage at doses equivalent to those associated with hepatic tumours (250 mg BHT/kg), suggests that chronic liver cell damage may be involved in their aetiology. In this and several other studies, there was no evidence that BHT causes liver damage at a dose level of 25 mg/kg/day. As this is several hundred times higher than the normal human intake, it is considered unlikely that BHT poses a threat to human health." @default.
• W2091583893 created "2016-06-24" @default.
• W2091583893 creator A5001824892 @default.
• W2091583893 creator A5012035759 @default.
• W2091583893 creator A5014247222 @default.
• W2091583893 creator A5030895459 @default.
• W2091583893 creator A5040403010 @default.
• W2091583893 date "1986-10-01" @default.
• W2091583893 modified "2023-10-12" @default.
• W2091583893 title "Hepatic responses to the administration of high doses of BHT to the rat: Their relevance to hepatocarcinogenicity" @default.
• W2091583893 cites W1498008296 @default.
• W2091583893 cites W1775749144 @default.
• W2091583893 cites W1990580720 @default.
• W2091583893 cites W1992286457 @default.
• W2091583893 cites W2012037556 @default.
• W2091583893 cites W2012294401 @default.
• W2091583893 cites W2012555038 @default.
• W2091583893 cites W2022622746 @default.
• W2091583893 cites W2023944033 @default.
• W2091583893 cites W2036355139 @default.
• W2091583893 cites W2040699921 @default.
• W2091583893 cites W2049305039 @default.
• W2091583893 cites W2062159559 @default.
• W2091583893 cites W2063178681 @default.
• W2091583893 cites W2069724852 @default.
• W2091583893 cites W2073960928 @default.
• W2091583893 cites W2087056626 @default.
• W2091583893 cites W2092285156 @default.
• W2091583893 cites W2111676450 @default.
• W2091583893 cites W2123006482 @default.
• W2091583893 cites W2211617398 @default.
• W2091583893 cites W2421533328 @default.
• W2091583893 cites W1995968355 @default.
• W2091583893 doi "https://doi.org/10.1016/0278-6915(86)90299-1" @default.
• W2091583893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3026937" @default.
• W2091583893 hasPublicationYear "1986" @default.
• W2091583893 type Work @default.
• W2091583893 sameAs 2091583893 @default.
• W2091583893 citedByCount "52" @default.
• W2091583893 countsByYear W20915838932012 @default.
• W2091583893 countsByYear W20915838932013 @default.
• W2091583893 countsByYear W20915838932015 @default.
• W2091583893 countsByYear W20915838932016 @default.
• W2091583893 countsByYear W20915838932017 @default.
• W2091583893 countsByYear W20915838932021 @default.
• W2091583893 countsByYear W20915838932022 @default.
• W2091583893 countsByYear W20915838932023 @default.
• W2091583893 crossrefType "journal-article" @default.
• W2091583893 hasAuthorship W2091583893A5001824892 @default.
• W2091583893 hasAuthorship W2091583893A5012035759 @default.
• W2091583893 hasAuthorship W2091583893A5014247222 @default.
• W2091583893 hasAuthorship W2091583893A5030895459 @default.
• W2091583893 hasAuthorship W2091583893A5040403010 @default.
• W2091583893 hasConcept C114246631 @default.
• W2091583893 hasConcept C126322002 @default.
• W2091583893 hasConcept C134018914 @default.
• W2091583893 hasConcept C160160445 @default.
• W2091583893 hasConcept C181199279 @default.
• W2091583893 hasConcept C185592680 @default.
• W2091583893 hasConcept C202751555 @default.
• W2091583893 hasConcept C2776200302 @default.
• W2091583893 hasConcept C2776637226 @default.
• W2091583893 hasConcept C2777562237 @default.
• W2091583893 hasConcept C2778004101 @default.
• W2091583893 hasConcept C2779661893 @default.
• W2091583893 hasConcept C2779864607 @default.
• W2091583893 hasConcept C29730261 @default.
• W2091583893 hasConcept C2992672570 @default.
• W2091583893 hasConcept C503630168 @default.
• W2091583893 hasConcept C55493867 @default.
• W2091583893 hasConcept C71924100 @default.
• W2091583893 hasConcept C98274493 @default.
• W2091583893 hasConceptScore W2091583893C114246631 @default.
• W2091583893 hasConceptScore W2091583893C126322002 @default.
• W2091583893 hasConceptScore W2091583893C134018914 @default.
• W2091583893 hasConceptScore W2091583893C160160445 @default.
• W2091583893 hasConceptScore W2091583893C181199279 @default.
• W2091583893 hasConceptScore W2091583893C185592680 @default.
• W2091583893 hasConceptScore W2091583893C202751555 @default.
• W2091583893 hasConceptScore W2091583893C2776200302 @default.
• W2091583893 hasConceptScore W2091583893C2776637226 @default.
• W2091583893 hasConceptScore W2091583893C2777562237 @default.
• W2091583893 hasConceptScore W2091583893C2778004101 @default.
• W2091583893 hasConceptScore W2091583893C2779661893 @default.
• W2091583893 hasConceptScore W2091583893C2779864607 @default.
• W2091583893 hasConceptScore W2091583893C29730261 @default.
• W2091583893 hasConceptScore W2091583893C2992672570 @default.
• W2091583893 hasConceptScore W2091583893C503630168 @default.
• W2091583893 hasConceptScore W2091583893C55493867 @default.
• W2091583893 hasConceptScore W2091583893C71924100 @default.
• W2091583893 hasConceptScore W2091583893C98274493 @default.
• W2091583893 hasIssue "10-11" @default.
• W2091583893 hasLocation W20915838931 @default.
• W2091583893 hasLocation W20915838932 @default.
• W2091583893 hasOpenAccess W2091583893 @default.
• W2091583893 hasPrimaryLocation W20915838931 @default.
• W2091583893 hasRelatedWork W179566324 @default.
• W2091583893 hasRelatedWork W2013989206 @default.

• next