Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091597225> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2091597225 endingPage "2064" @default.
- W2091597225 startingPage "2059" @default.
- W2091597225 abstract "To investigate the functional implications of CD44 splice variant expression in fibroblast-like synoviocytes (FLS) obtained from patients with rheumatoid arthritis (RA).FLS were isolated from synovial tissue obtained from both diseased and nondiseased joints. The expression of splice variants containing exons v3 and v6 was analyzed using immunocytochemistry with exon-specific antibodies and reverse transcription-polymerase chain reaction followed by Southern blotting. The invasive capacity of the cells was studied in a transwell invasion assay.FLS obtained from RA joints expressed various CD44 splicing combinations containing the variant exons v3 and/or v6. These cells were highly invasive, whereas cells from normal tissues, which lacked expression of CD44 splice variants, were not. Variant exons CD44v3 and CD44v6 were instrumental in matrix invasion in vitro, with cells enriched for CD44v3 and v6 exhibiting greater invasion and antibodies that specifically recognize CD44v3 and v6 abrogating this capacity to invade. Invasive cells showed a reduced expression of CD44v7/8, and antibodies against this epitope had no significant effect on cellular infiltration of the matrix. The antibodies had no effect on cell migration into the porous section of the transwell.FLS obtained from patients with RA express CD44 splice variants and are highly invasive, whereas cells obtained from healthy tissue do not express these variants and are not invasive. Expression of the epitopes CD44v3 and CD44v6 is instrumental in the invasive capacity but not in cell migration. This finding highlights a functional implication for the expression of CD44 splice variants at the level of matrix degradation." @default.
- W2091597225 created "2016-06-24" @default.
- W2091597225 creator A5007964369 @default.
- W2091597225 creator A5020057358 @default.
- W2091597225 creator A5045071155 @default.
- W2091597225 creator A5050056073 @default.
- W2091597225 creator A5056677311 @default.
- W2091597225 creator A5087557221 @default.
- W2091597225 creator A5089096091 @default.
- W2091597225 date "2002-08-01" @default.
- W2091597225 modified "2023-10-09" @default.
- W2091597225 title "Influence of epitopes CD44v3 and CD44v6 in the invasive behavior of fibroblast-like synoviocytes derived from rheumatoid arthritic joints" @default.
- W2091597225 cites W1588921208 @default.
- W2091597225 cites W1985585224 @default.
- W2091597225 cites W2022243451 @default.
- W2091597225 cites W2029596865 @default.
- W2091597225 cites W2049520205 @default.
- W2091597225 cites W2054020967 @default.
- W2091597225 cites W2057325749 @default.
- W2091597225 cites W2059368255 @default.
- W2091597225 cites W2095204857 @default.
- W2091597225 cites W2105367923 @default.
- W2091597225 cites W2114964393 @default.
- W2091597225 cites W2125947059 @default.
- W2091597225 cites W2132346873 @default.
- W2091597225 cites W2152348310 @default.
- W2091597225 doi "https://doi.org/10.1002/art.10421" @default.
- W2091597225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12209509" @default.
- W2091597225 hasPublicationYear "2002" @default.
- W2091597225 type Work @default.
- W2091597225 sameAs 2091597225 @default.
- W2091597225 citedByCount "35" @default.
- W2091597225 countsByYear W20915972252012 @default.
- W2091597225 countsByYear W20915972252013 @default.
- W2091597225 countsByYear W20915972252014 @default.
- W2091597225 countsByYear W20915972252015 @default.
- W2091597225 countsByYear W20915972252016 @default.
- W2091597225 countsByYear W20915972252018 @default.
- W2091597225 countsByYear W20915972252021 @default.
- W2091597225 countsByYear W20915972252022 @default.
- W2091597225 crossrefType "journal-article" @default.
- W2091597225 hasAuthorship W2091597225A5007964369 @default.
- W2091597225 hasAuthorship W2091597225A5020057358 @default.
- W2091597225 hasAuthorship W2091597225A5045071155 @default.
- W2091597225 hasAuthorship W2091597225A5050056073 @default.
- W2091597225 hasAuthorship W2091597225A5056677311 @default.
- W2091597225 hasAuthorship W2091597225A5087557221 @default.
- W2091597225 hasAuthorship W2091597225A5089096091 @default.
- W2091597225 hasBestOaLocation W20915972252 @default.
- W2091597225 hasConcept C104317684 @default.
- W2091597225 hasConcept C1491633281 @default.
- W2091597225 hasConcept C153911025 @default.
- W2091597225 hasConcept C159654299 @default.
- W2091597225 hasConcept C195616568 @default.
- W2091597225 hasConcept C203014093 @default.
- W2091597225 hasConcept C2780381497 @default.
- W2091597225 hasConcept C2780932548 @default.
- W2091597225 hasConcept C2780989783 @default.
- W2091597225 hasConcept C36823959 @default.
- W2091597225 hasConcept C54355233 @default.
- W2091597225 hasConcept C81885089 @default.
- W2091597225 hasConcept C86803240 @default.
- W2091597225 hasConcept C95444343 @default.
- W2091597225 hasConceptScore W2091597225C104317684 @default.
- W2091597225 hasConceptScore W2091597225C1491633281 @default.
- W2091597225 hasConceptScore W2091597225C153911025 @default.
- W2091597225 hasConceptScore W2091597225C159654299 @default.
- W2091597225 hasConceptScore W2091597225C195616568 @default.
- W2091597225 hasConceptScore W2091597225C203014093 @default.
- W2091597225 hasConceptScore W2091597225C2780381497 @default.
- W2091597225 hasConceptScore W2091597225C2780932548 @default.
- W2091597225 hasConceptScore W2091597225C2780989783 @default.
- W2091597225 hasConceptScore W2091597225C36823959 @default.
- W2091597225 hasConceptScore W2091597225C54355233 @default.
- W2091597225 hasConceptScore W2091597225C81885089 @default.
- W2091597225 hasConceptScore W2091597225C86803240 @default.
- W2091597225 hasConceptScore W2091597225C95444343 @default.
- W2091597225 hasIssue "8" @default.
- W2091597225 hasLocation W20915972251 @default.
- W2091597225 hasLocation W20915972252 @default.
- W2091597225 hasLocation W20915972253 @default.
- W2091597225 hasOpenAccess W2091597225 @default.
- W2091597225 hasPrimaryLocation W20915972251 @default.
- W2091597225 hasRelatedWork W1979044599 @default.
- W2091597225 hasRelatedWork W2009867644 @default.
- W2091597225 hasRelatedWork W2013066109 @default.
- W2091597225 hasRelatedWork W2021824670 @default.
- W2091597225 hasRelatedWork W2068174058 @default.
- W2091597225 hasRelatedWork W2093822539 @default.
- W2091597225 hasRelatedWork W2166782903 @default.
- W2091597225 hasRelatedWork W2363997565 @default.
- W2091597225 hasRelatedWork W3036615648 @default.
- W2091597225 hasRelatedWork W1981120125 @default.
- W2091597225 hasVolume "46" @default.
- W2091597225 isParatext "false" @default.
- W2091597225 isRetracted "false" @default.
- W2091597225 magId "2091597225" @default.
- W2091597225 workType "article" @default.