FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091601461> ?p ?o ?g. }

• W2091601461 endingPage "24520" @default.
• W2091601461 startingPage "24512" @default.
• W2091601461 abstract "Conformational mobility of the distal histidine residue has been implicated for several different heme peroxidase enzymes, but unambiguous structural evidence is not available. In this work, we present mechanistic, spectroscopic, and structural evidence for peroxide- and ligand-induced conformational mobility of the distal histidine residue (His-42) in a site-directed variant of ascorbate peroxidase (W41A). In this variant, His-42 binds on to the heme in the oxidized form, duplicating the active site structure of the cytochromes b but, in contrast to the cytochromes b, is able to swing off the iron during catalysis. This conformational flexibility between the on and off forms is fully reversible and is used as a means to overcome the inherently unreactive nature of the on form toward peroxide, so that essentially complete catalytic activity is maintained. Contrary to the widely adopted view of heme enzyme catalysis, these data indicate that strong coordination of the distal histidine to the heme iron does not automatically undermine catalytic activity. The data add a new dimension to our wider appreciation of structure/activity correlations in other heme enzymes." @default.
• W2091601461 created "2016-06-24" @default.
• W2091601461 creator A5009739452 @default.
• W2091601461 creator A5018501848 @default.
• W2091601461 creator A5022071886 @default.
• W2091601461 creator A5030207149 @default.
• W2091601461 creator A5035078258 @default.
• W2091601461 creator A5047909325 @default.
• W2091601461 creator A5056647695 @default.
• W2091601461 creator A5072810164 @default.
• W2091601461 creator A5083133972 @default.
• W2091601461 date "2006-08-01" @default.
• W2091601461 modified "2023-10-17" @default.
• W2091601461 title "Conformational Mobility in the Active Site of a Heme Peroxidase" @default.
• W2091601461 cites W1522027655 @default.
• W2091601461 cites W1966828832 @default.
• W2091601461 cites W1978044046 @default.
• W2091601461 cites W1983156813 @default.
• W2091601461 cites W1986432247 @default.
• W2091601461 cites W1991774630 @default.
• W2091601461 cites W1992823853 @default.
• W2091601461 cites W1995002017 @default.
• W2091601461 cites W1995873072 @default.
• W2091601461 cites W2001641653 @default.
• W2091601461 cites W2003881693 @default.
• W2091601461 cites W2011184991 @default.
• W2091601461 cites W2023042894 @default.
• W2091601461 cites W2024082951 @default.
• W2091601461 cites W2038840577 @default.
• W2091601461 cites W2039042657 @default.
• W2091601461 cites W2048459982 @default.
• W2091601461 cites W2050911622 @default.
• W2091601461 cites W2055955041 @default.
• W2091601461 cites W2063368322 @default.
• W2091601461 cites W2067501823 @default.
• W2091601461 cites W2070385082 @default.
• W2091601461 cites W2071593932 @default.
• W2091601461 cites W2073134958 @default.
• W2091601461 cites W2082809953 @default.
• W2091601461 cites W2093377100 @default.
• W2091601461 cites W2110810524 @default.
• W2091601461 cites W2119350234 @default.
• W2091601461 cites W2136567909 @default.
• W2091601461 cites W2138393107 @default.
• W2091601461 cites W2144081223 @default.
• W2091601461 cites W2952565004 @default.
• W2091601461 doi "https://doi.org/10.1074/jbc.m602602200" @default.
• W2091601461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16762924" @default.
• W2091601461 hasPublicationYear "2006" @default.
• W2091601461 type Work @default.
• W2091601461 sameAs 2091601461 @default.
• W2091601461 citedByCount "27" @default.
• W2091601461 countsByYear W20916014612012 @default.
• W2091601461 countsByYear W20916014612013 @default.
• W2091601461 countsByYear W20916014612014 @default.
• W2091601461 countsByYear W20916014612016 @default.
• W2091601461 countsByYear W20916014612018 @default.
• W2091601461 countsByYear W20916014612019 @default.
• W2091601461 countsByYear W20916014612020 @default.
• W2091601461 countsByYear W20916014612021 @default.
• W2091601461 countsByYear W20916014612023 @default.
• W2091601461 crossrefType "journal-article" @default.
• W2091601461 hasAuthorship W2091601461A5009739452 @default.
• W2091601461 hasAuthorship W2091601461A5018501848 @default.
• W2091601461 hasAuthorship W2091601461A5022071886 @default.
• W2091601461 hasAuthorship W2091601461A5030207149 @default.
• W2091601461 hasAuthorship W2091601461A5035078258 @default.
• W2091601461 hasAuthorship W2091601461A5047909325 @default.
• W2091601461 hasAuthorship W2091601461A5056647695 @default.
• W2091601461 hasAuthorship W2091601461A5072810164 @default.
• W2091601461 hasAuthorship W2091601461A5083133972 @default.
• W2091601461 hasBestOaLocation W20916014611 @default.
• W2091601461 hasConcept C133166286 @default.
• W2091601461 hasConcept C162008176 @default.
• W2091601461 hasConcept C178790620 @default.
• W2091601461 hasConcept C181199279 @default.
• W2091601461 hasConcept C185592680 @default.
• W2091601461 hasConcept C2776217839 @default.
• W2091601461 hasConcept C2778460671 @default.
• W2091601461 hasConcept C2781048764 @default.
• W2091601461 hasConcept C2781338088 @default.
• W2091601461 hasConcept C41183919 @default.
• W2091601461 hasConcept C55493867 @default.
• W2091601461 hasConcept C71240020 @default.
• W2091601461 hasConceptScore W2091601461C133166286 @default.
• W2091601461 hasConceptScore W2091601461C162008176 @default.
• W2091601461 hasConceptScore W2091601461C178790620 @default.
• W2091601461 hasConceptScore W2091601461C181199279 @default.
• W2091601461 hasConceptScore W2091601461C185592680 @default.
• W2091601461 hasConceptScore W2091601461C2776217839 @default.
• W2091601461 hasConceptScore W2091601461C2778460671 @default.
• W2091601461 hasConceptScore W2091601461C2781048764 @default.
• W2091601461 hasConceptScore W2091601461C2781338088 @default.
• W2091601461 hasConceptScore W2091601461C41183919 @default.
• W2091601461 hasConceptScore W2091601461C55493867 @default.
• W2091601461 hasConceptScore W2091601461C71240020 @default.
• W2091601461 hasIssue "34" @default.
• W2091601461 hasLocation W20916014611 @default.

• next