FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091609632> ?p ?o ?g. }

• W2091609632 endingPage "275" @default.
• W2091609632 startingPage "265" @default.
• W2091609632 abstract "There are several lines of evidence that the modification of proteins by cytosolic- and nuclear-specific O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is closely related to neuropathologies, particularly Alzheimer's disease. Several neuronal proteins have been identified as being modified with O-GlcNAc; these proteins could form part of the inclusion bodies found, for example, in the most frequently observed neurologic disorder (i.e., Alzheimer's disease; Tau protein and beta-amyloid peptide are the well known aggregated proteins). O-GlcNAc proteins are also implicated in synaptosomal transport (e.g., synapsins and clathrin-assembly proteins). Inclusion bodies are partly characterized by a deficiency in the ubiquitin-proteasome system, avoiding the degradation of aggregated proteins. From this perspective, it appears interesting that substrate proteins could be protected against proteasomal degradation by being covalently modified with single N-acetylglucosamine on serine or threonine, and that the proteasome itself is modified and regulated by O-GlcNAc (in this case the turnover of neuronal proteins correlates with extracellular glucose). Interestingly, glucose uptake and metabolism are impaired in neuronal disorders, and this phenomenon is linked to increased phosphorylation. In view of the existence of the dynamic interplay between O-GlcNAc and phosphorylation, it is tempting to draw a parallel between the use of glucose, O-GlcNAc glycosylation and phosphorylation. Lastly, the two enzymes responsible for O-GlcNAc dynamism (i.e., O-GlcNAc transferase and glucosaminidase) are both enriched in the brain and genes that encode the two enzymes are located in two regions that are found to be frequently mutated in neurologic disorders. The data presented in this review strongly suggest that O-GlcNAc could play an active role in neurodegenerative diseases." @default.
• W2091609632 created "2016-06-24" @default.
• W2091609632 creator A5000688638 @default.
• W2091609632 creator A5050734955 @default.
• W2091609632 creator A5073178776 @default.
• W2091609632 creator A5075136099 @default.
• W2091609632 creator A5080220307 @default.
• W2091609632 creator A5080338012 @default.
• W2091609632 date "2005-04-01" @default.
• W2091609632 modified "2023-10-16" @default.
• W2091609632 title "Does<i>O</i>-GlcNAc play a role in neurodegenerative diseases?" @default.
• W2091609632 cites W1481480776 @default.
• W2091609632 cites W1504722292 @default.
• W2091609632 cites W1540964771 @default.
• W2091609632 cites W1549549393 @default.
• W2091609632 cites W1554689987 @default.
• W2091609632 cites W1568866400 @default.
• W2091609632 cites W1577662346 @default.
• W2091609632 cites W1840520099 @default.
• W2091609632 cites W190025346 @default.
• W2091609632 cites W1969939865 @default.
• W2091609632 cites W1970979133 @default.
• W2091609632 cites W1975166375 @default.
• W2091609632 cites W1982436563 @default.
• W2091609632 cites W1984507653 @default.
• W2091609632 cites W1986758311 @default.
• W2091609632 cites W1987963824 @default.
• W2091609632 cites W1994396628 @default.
• W2091609632 cites W1997369314 @default.
• W2091609632 cites W1998020365 @default.
• W2091609632 cites W1998044291 @default.
• W2091609632 cites W1999351520 @default.
• W2091609632 cites W2002559713 @default.
• W2091609632 cites W2002813635 @default.
• W2091609632 cites W2002888609 @default.
• W2091609632 cites W2009324889 @default.
• W2091609632 cites W2012232758 @default.
• W2091609632 cites W2013687829 @default.
• W2091609632 cites W2015923950 @default.
• W2091609632 cites W2023588697 @default.
• W2091609632 cites W2031087463 @default.
• W2091609632 cites W2033611838 @default.
• W2091609632 cites W2036260456 @default.
• W2091609632 cites W2037909830 @default.
• W2091609632 cites W2041379353 @default.
• W2091609632 cites W2041967294 @default.
• W2091609632 cites W2044688375 @default.
• W2091609632 cites W2047096855 @default.
• W2091609632 cites W2049020770 @default.
• W2091609632 cites W2051948190 @default.
• W2091609632 cites W2054619408 @default.
• W2091609632 cites W2066371153 @default.
• W2091609632 cites W2073750692 @default.
• W2091609632 cites W2076430609 @default.
• W2091609632 cites W2080322109 @default.
• W2091609632 cites W2091757744 @default.
• W2091609632 cites W2100617913 @default.
• W2091609632 cites W2108966929 @default.
• W2091609632 cites W2115836749 @default.
• W2091609632 cites W2118488166 @default.
• W2091609632 cites W2119830445 @default.
• W2091609632 cites W2121743106 @default.
• W2091609632 cites W2122073557 @default.
• W2091609632 cites W2128348740 @default.
• W2091609632 cites W2131581447 @default.
• W2091609632 cites W2146282045 @default.
• W2091609632 cites W2149202312 @default.
• W2091609632 cites W2155360303 @default.
• W2091609632 cites W2161157580 @default.
• W2091609632 cites W2164029759 @default.
• W2091609632 cites W2164933850 @default.
• W2091609632 cites W2166036638 @default.
• W2091609632 cites W4247365895 @default.
• W2091609632 cites W47487143 @default.
• W2091609632 doi "https://doi.org/10.1586/14789450.2.2.265" @default.
• W2091609632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15892570" @default.
• W2091609632 hasPublicationYear "2005" @default.
• W2091609632 type Work @default.
• W2091609632 sameAs 2091609632 @default.
• W2091609632 citedByCount "50" @default.
• W2091609632 countsByYear W20916096322012 @default.
• W2091609632 countsByYear W20916096322013 @default.
• W2091609632 countsByYear W20916096322014 @default.
• W2091609632 countsByYear W20916096322015 @default.
• W2091609632 countsByYear W20916096322016 @default.
• W2091609632 countsByYear W20916096322017 @default.
• W2091609632 countsByYear W20916096322018 @default.
• W2091609632 countsByYear W20916096322019 @default.
• W2091609632 countsByYear W20916096322020 @default.
• W2091609632 countsByYear W20916096322021 @default.
• W2091609632 countsByYear W20916096322022 @default.
• W2091609632 countsByYear W20916096322023 @default.
• W2091609632 crossrefType "journal-article" @default.
• W2091609632 hasAuthorship W2091609632A5000688638 @default.
• W2091609632 hasAuthorship W2091609632A5050734955 @default.
• W2091609632 hasAuthorship W2091609632A5073178776 @default.
• W2091609632 hasAuthorship W2091609632A5075136099 @default.
• W2091609632 hasAuthorship W2091609632A5080220307 @default.

• next