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• W2091621930 startingPage "2836" @default.
• W2091621930 abstract "ABSTRACT One of the early steps in the biosynthesis of coenzyme F 420 in Methanocaldococcus jannaschii requires generation of 2-phospho- l -lactate, which is formed by the phosphorylation of l -lactate. Preliminary studies had shown that l -lactate in M. jannaschii is not derived from pyruvate, and thus an alternate pathway(s) for its formation was examined. Here we report that l -lactate is formed by the NAD + -dependent oxidation of l -lactaldehyde by the MJ1411 gene product. The lactaldehyde, in turn, was found to be generated either by the NAD(P)H reduction of methylglyoxal or by the aldol cleavage of fuculose-1-phosphate by fuculose-1-phosphate aldolase, the MJ1418 gene product." @default.
• W2091621930 created "2016-06-24" @default.
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• W2091621930 date "2006-04-15" @default.
• W2091621930 modified "2023-10-03" @default.
• W2091621930 title "Identification of Lactaldehyde Dehydrogenase in <i>Methanocaldococcus jannaschii</i> and Its Involvement in Production of Lactate for F ₄₂₀ Biosynthesis" @default.
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• W2091621930 doi "https://doi.org/10.1128/jb.188.8.2836-2844.2006" @default.
• W2091621930 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1447007" @default.
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