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- W2091632217 abstract "We have compared in mice the overall toxicity of free adriamycin (ADR) or DNA bound adriamycin (ADR-DNA) after repeated i.v. injections of high drug doses (35–40 mg/kg). Survival curves and variations in mean total body weight indicated that ADR-DNA is less toxic than ADR in mice. Histopathologic studies showed: (1) that ADR induced severe lesions in the hemopoietic organs (bone marrow, lymph nodes, spleen, thymus) and in the gastrointestinal tract. An important lipid overloading in liver and kidney was observed; (2) that the toxicity of ADR is reduced for bone marrow and stomach when the drug is associated with high mol. wt DNA. No lipid overloading has been seen in liver and kidney of the complex treated mice. The repair of the lesions induced in the tissues (lymphoid organs, thymus) which are not protected against the effect of ADR when using a DNA-complex, is significantly more rapid. Finally, in this subacute study in mice, no cardiomyopathy has been observed after treatment with either free or DNA bound drug." @default.
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- W2091632217 date "1980-08-01" @default.
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- W2091632217 title "DNA—Anthracycline complexes. II. Comparative study of the acute lesions induced in mice after intravenous administration of free and DNA bound adriamycin" @default.
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- W2091632217 doi "https://doi.org/10.1016/0014-2964(80)90244-3" @default.
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